Isoorientin Explained

Isoorientin (or homoorientin) is a flavone, a chemical flavonoid-like compound. It is the luteolin-6-C-glucoside. Bioassay-directed fractionation techniques led to isolation of isoorientin as the main hypoglycaemic component in Gentiana olivieri.^[1] Studies also showed that isoorientin is a potential neuroprotective compound against Alzheimer's disease.^[2]

Natural occurrences

Isoorientin can be isolated from the passion flower, Vitex negundo, Terminalia myriocarpa, the Açaí palm and Swertia japonica.

Metabolism

• Isoorientin 3'-O-methyltransferase

See also

• Orientin, the 8-C glucoside of luteolin.

Notes and References

1. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques. Ekrem Sezik, Mustafa Aslan, Erdem Yesilada, Shigeru Ito, Life Sciences, 28 January 2005, Volume 76, Issue 11, Pages 1223–1238,
2. Zhibin Liang . Bei Zhang . Wei Wen Su . Philip G Williams . Qing X Li . C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition . ACS Chemical Neuroscience . 7 . July 2016 . 912–923 . 27213824 . 10.1021/acschemneuro.6b00059 . 7355085 .