Isometamidium chloride explained

Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine.^{[1] [2]}

It consists of a single ethidium bromide like subunit linked to a fragment of the diminazene molecule.

Resistance

The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, T. congolense isolated from Boran cattle.

Notes and References

1. Whitelaw DD, Bell IR, Holmes PH, Moloo SK, Hirumi H, Urquhart GM, Murray M . Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle . The Veterinary Record . 118 . 26 . 722–6 . June 1986 . 3739193 . 10.1136/vr.118.26.722 . 39168151 .
2. Peregrine AS, Ogunyemi O, Whitelaw DD, Holmes PH, Moloo SK, Hirumi H, Urquhart GM, Murray M . 6 . Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense . Veterinary Parasitology . 28 . 1–2 . 53–64 . April 1988 . 3388736 . 10.1016/0304-4017(88)90018-0 .