Isolated organ perfusion technique explained

Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery. The technique has been widely studied in animal and human for decades.[1] [2] [3] [4] [5] [6] [7] Before the implementation, the perfusion system will be selected and the process can be similar to organ bath.[8] Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole out of the body.[9]

See also

Notes and References

  1. Cypel . Marcelo . Keshavjee . Shaf . Novel Technologies for Isolated Lung Perfusion . Thoracic Surgery Clinics . Elsevier BV . 26 . 2 . 2016 . 1547-4127 . 10.1016/j.thorsurg.2015.12.002 . 139–145. 27112253 .
  2. Eiseman . B. . Knipe . Peter . McCOLL . H. A. . Orloff . M. J. . Isolated Liver Perfusion for Reducing Blood Ammonia . Archives of Surgery . 83 . 3 . 1961-09-01 . 0004-0010 . 10.1001/archsurg.1961.01300150030004 . 356–363 . 13726167 . 2019-06-30.
  3. Web site: Isolated Organ Perfusion Studies - Physiology . Harvard Apparatus . 2019-06-30 . https://web.archive.org/web/20190513041238/https://www.harvardapparatus.com/physiology/isolated-organ-perfusion-studies.html . 2019-05-13 . live .
  4. Abbott . William M. . Weinerth . John L. . The perfusion of isolated whole organs . Cryobiology . Elsevier BV . 8 . 2 . 1971 . 0011-2240 . 10.1016/0011-2240(71)90019-8 . 113–133. 5578880 .
  5. Guyette . Jacques P . Gilpin . Sarah E . Charest . Jonathan M . Tapias . Luis F . Ren . Xi . Ott . Harald C . Perfusion decellularization of whole organs . Nature Protocols . Springer Science and Business Media LLC . 9 . 6 . 2014-05-29 . 1754-2189 . 10.1038/nprot.2014.097 . 24874812 . 1451–1468. 7397409 .
  6. Book: Schjørring . Olav L. . Carlsson . Rune . Simonsen . Ulf . Methods in Mouse Atherosclerosis . 1339 . Pressure Myography to Study the Function and Structure of Isolated Small Arteries . Methods in Molecular Biology . Springer New York . New York, NY . 2015 . 978-1-4939-2928-3 . 1064-3745 . 10.1007/978-1-4939-2929-0_19 . 26445796 . 277–295.
  7. Serrat . Maria A . Measuring bone blood supply in mice using fluorescent microspheres . Nature Protocols . Springer Science and Business Media LLC . 4 . 12 . 2009-11-05 . 1754-2189 . 10.1038/nprot.2009.190 . 19893510 . 1749–1758. 29637802 .
  8. Web site: Tissue bath . 2019-06-30 . https://web.archive.org/web/20170618163523/http://www.harvardapparatus.com/media/harvard/pdf/Perfusion+Systems+Selection+Guide.pdf . 2017-06-18 . live .
  9. Book: Yeh . T. . Wechsler . A. S. . Surgical Research . The Isolated Organ in Research . Springer New York . New York, NY . 1998 . 978-1-4612-7325-7 . 10.1007/978-1-4612-1888-3_49 . 435–452. Technological advances in artificial perfusion allow effective isolated perfusion of a wide variety of organs and tissues, including, but not limited to, brain, heart, lung, heart-lung, liver, kidney, spleen, pancreas, thymus, gastrointestinal tract, urinary tract, reproductive tract, skeletal muscle, nerves, and blood vessels. .

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