| Isola del Gran Sasso d'Italia | |
| Official Name: | Comune di Isola del Gran Sasso d'Italia |
| Coordinates: | 42.5°N 53°W |
| Region: | Abruzzo |
| Province: | Teramo (TE) |
| Frazioni: | Capsano, Casale San Nicola, Cerchiara, Ceriseto, Cesa di Francia, Colliberti, Fano a Corno, Forca di Valle, Pretara, San Gabriele dell'Addolorata, San Massimo, San Pietro, Trignano, Varano |
| Mayor: | Andrea Ianni |
| Area Total Km2: | 83 |
| Population Total: | 4789 |
| Population As Of: | 30 November 2014 |
| Population Demonym: | Isolani |
| Elevation M: | 498 |
| Saint: | Saint Massimo |
| Day: | First Sunday in May |
| Postal Code: | 64045 |
| Area Code: | 0861 |
Isola del Gran Sasso d'Italia is a town and comune in province of Teramo in the Abruzzo region of southern Italy. It is located in the Gran Sasso e Monti della Laga National Park. The Gran Sasso mountain is the highest mountain in the Apennine chain in Italy.