Isocitrate dehydrogenase (NADP+) kinase explained
[isocitrate dehydrogenase (NADP+)] kinase |
Ec Number: | 2.7.11.5 |
Cas Number: | 83682-93-3 |
Go Code: | 0008772 |
In enzymology, a [isocitrate dehydrogenase (NADP+)] kinase is an enzyme that catalyzes the chemical reaction:
ATP + [isocitrate dehydrogenase (NADP<sup>+</sup>)]
ADP + [isocitrate dehydrogenase (NADP<sup>+</sup>)] phosphate
Thus, the two substrates of this enzyme are ATP and isocitrate dehydrogenase (NADP+), whereas its two products are ADP and isocitrate dehydrogenase (NADP+) phosphate.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).
Other names
The systematic name of this enzyme class is ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase. Other names in common use include [isocitrate dehydrogenase (NADP+)] kinase, ICDH kinase/phosphatase, IDH kinase, IDH kinase/phosphatase, IDH-K/P, IDHK/P, isocitrate dehydrogenase kinase (phosphorylating), isocitrate dehydrogenase kinase/phosphatase, and STK3.
References
- Wang JY, Koshland DE . 1982 . The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium . Arch. Biochem. Biophys. . 218 . 59 - 67 . 6756316 . 10.1016/0003-9861(82)90321-6 . 1 .
- Miller SP, Karschnia EJ, Ikeda TP, LaPorte DC . 1996 . Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins . J. Biol. Chem. . 271 . 19124 - 8 . 8702587 . 10.1074/jbc.271.32.19124 . 32 . free .
- Singh SK, Matsuno K, LaPorte DC, Banaszak LJ . 2001 . Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase . J. Biol. Chem. . 276 . 26154 - 63 . 11290745 . 10.1074/jbc.M101191200 . 28 . free .
- Jault JM . 2001 . The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases . Biochemistry . 40 . 3047 - 55 . 11258918 . 10.1021/bi001713x . Cortay . JC . Blanchet . C . Laporte . DC . Di Pietro . A . Cozzone . AJ . Jault . JM . 10 .