| Isla Santiago | |
| Image Caption: | Isla Santiago |
| Map: | Mexico |
| Location: | Gulf of California, Loreto Municipality |
| Coordinates: | 26.1057°N -111.3053°W |
| Elevation M: | 20 |
| Country: | Mexico |
| Country Admin Divisions Title: | State |
| Country Admin Divisions: | Baja California Sur |
| Population: | Uninhabited |
Isla Santiago, is an island in the Gulf of California, east of the Baja California Peninsula in Baja California Sur state.
The uninhabited island is within Loreto Municipality.
Isla Santiago has only one species of reptile, the desert iguana (Dipsosaurus dorsalis).[1]