| Honorific-Prefix: | His Excellency |
| Isidro Ayora | |
| Order: | 22nd |
| Office: | President of Ecuador |
| Predecessor: | Himself (as Interim President) |
| Successor: | Luis Larrea Alba |
| Term Start: | 17 April 1929 |
| Term End: | 24 August 1931 |
| Office2: | Interim President of Ecuador |
| Term Start2: | 6 April 1926 |
| Term End2: | 17 April 1929 |
| Predecessor2: | Julio Enrique Moreno |
| Successor2: | Himself (as President) |
| Birth Name: | Isidro Ramon Antonio Ayora Cueva |
| Birth Date: | 31 August 1879 |
| Birth Place: | Loja, Ecuador |
| Death Place: | Los Angeles, California, U.S. |
| Party: | Ecuadorian Radical Liberal Party |
| Alma Mater: | Central University of Ecuador |
| Profession: | Doctor |
Isidro Ramon Antonio Ayora Cueva (31 August 1879[1] – 22 March 1978)[2] was an Ecuadorian political figure. He served as the 22nd President of Ecuador from 1926 to 1931. Isidro Ayora, a town in Guayas, and Puerto Ayora, are named after him. Some people name coins ayora because they were introduced by him.
Upon his death in 1978 at age 98, Ayora was the longest-living Ecuadorian president; until his record was surpassed by Guillermo Rodríguez in 2023, when Rodríguez turn 100.[3]