| Native Name: | 伊勢崎藩 |
| Conventional Long Name: | Isesaki Domain |
| Common Name: | Isesaki Domain |
| Subdivision: | Han |
| Status Text: | under Tokugawa shogunate Japan |
| Government Type: | Daimyō |
| Today: | part of Gunma Prefecture |
| Year Start: | 1601 |
| Year End: | 1871 |
| Era: | Edo period |
was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Kōzuke Province (modern-day Gunma Prefecture), Japan. It was centered on Isesaki jin'ya in what is now part of the city of Isesaki, Gunma. Isesaki was ruled through most of its history by a junior branch of the Sakai clan.
Isesaki Domain was originally created in 1601 for Inagaki Nagashige, a hatamoto formerly in the service of the Imagawa clan who had transferred his allegiance to Tokugawa Ieyasu. After Tokugawa Ieyasu took control over the Kantō region in 1590, he assigned estates with revenues of 3000 koku to Inagaki Nagashige in Kōzuke Province, and entrusted him with the defense of Ogo Castle. He was awarded additional estates in 1601, following Ieyasu’s defeat at the hands of Uesugi Kagekatsu at Aizu, which elevated him to the rank of daimyō. His son was transferred in 1616, and Isesaki was thereafter ruled by three junior branches of the Sakai clan until the end of the Edo period.
During the Bakumatsu period, forces of Iseskai Domain played a role in the suppression of the Tengutō Rebellion; however the next-to-last daimyo, Sakai Tadatsuyo was quick to join the imperial side in the Boshin War. After the end of the conflict, with the abolition of the han system in July 1871, Isesaki Domain became "Isesaki Prefecture", which later became part of Gunma Prefecture.
The domain had a population of 1964 samurai in 520 households per a census in 1763.[1]
Unlike most domains in the han system, which consisted of several discontinuous territories calculated to provide the assigned kokudaka, based on periodic cadastral surveys and projected agricultural yields,[2] [3] Isesaki was a relatively compact territory.
| Name | Tenure | Courtesy title | Court Rank | kokudaka | |
| Inagaki clan (fudai) 1601–1616 | |||||
| 1 | 1601–1612 | -none- | -unknown- | 10,000 koku | |
| 2 | 1612–1616 | Settsu-no-kami (摂津守) | Lower 5th (従五 位下) | 10,000 koku | |
| Sakai clan (fudai) 1600–1616 | |||||
| 1 | 1616–1617 | Uta-no-kami (雅楽頭); Jijū (侍従) | Lower 4th (従四位下) | 52,000 koku | |
| Sakai clan (fudai) 1636–1662 | |||||
| 1 | 1636–1662 | Hyūga-no-kami(日向守) | Lower 5th (従五位下) | 22,500 koku | |
| Sakai clan (fudai) 1617–1871 | |||||
| 1 | 1617–1619 | Shimotsuke-no-kami (下野守) | Lower 5th (従五位下) | 20,000 koku | |
| 2 | 1745–1749 | Shimotsuke-no-kami (下野守) | Lower 5th (従五位下) | 20,000 koku | |
| 3 | 1749–1781 | Suruga-no-kami (駿河守) | Lower 5th (従五位下) | 20,000 koku | |
| 4 | 1781–1800 | Shimotsuke-no-kami (下野守) | Lower 5th (従五位下) | 20,000 koku | |
| 5 | 1800–1825 | Shinano-no-kami (信濃守) | Lower 5th (従五位下) | 20,000 koku | |
| 6 | 1800–1839 | Iga-no-kami (伊賀守) | Lower 5th (従五位下) | 20,000 koku | |
| 7 | 1839–1840 | Shima-no-kami (志摩守) | Lower 5th (従五位下) | 20,000 koku | |
| 8 | 1840–1846 | Shimotsuke-no-kami (下野守) | Lower 5th (従五位下) | 20,000 koku | |
| 9 | 1847–1860 | Shimotsuke-no-kami (下野守) | Lower 5th (従五位下) | 20,000 koku | |