Isepamicin Explained

Isepamicin (isepamycin) is an aminoglycoside antibiotic.

It was patented in 1973 and approved for medical use in 1988.^[1] It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.^[2]

Synthesis

Isepamicin can be synthesized by derivatization of gentamicin B (1) with benzyl N-[(2''S'')-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate (2), followed by deprotection.^{[3] [4] [5] [6]}

Notes and References

1. Book: Fischer J, Ganellin CR . Analogue-based Drug Discovery . 2006 . John Wiley & Sons . 9783527607495 . 508 . en.
2. Web site: World Health Organization . 2012 . Critically important antimicrobials for human medicine..
3. Serradell, MN; Blancafort, P.; Roberts, PJ; Castaer, J.; SCH-21420. Drugs Fut 1979, 4, 7, 525.
4. John J. Wright, (1977 to Merck Sharp and Dohme Corp).
5. https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-09-0060 Thieme
6. https://www.chemdrug.com/article/8/3284/16419317.html ChemDrug