| Party: | African National Congress |
| Office1: | Member of the National Assembly |
| Termstart1: | June 1999 |
| Termend1: | February 2001 |
| Birth Date: | 1 April 1966 |
| Death Date: | February 2001 (aged 34) |
| Birth Name: | Isaiah Boy Ntshangase |
| Birth Place: | Pongola, Natal Province South Africa |
| Constituency1: | KwaZulu-Natal |
Isaiah Boy Ntshangase (1 April 1966 – February 2001) was a South African politician who represented the African National Congress (ANC) in the National Assembly from 1999 until his death in 2001. A lionised figure in the ANC Youth League, he was provincial chairperson of the league's KwaZulu-Natal branch from 1996 to 2000. Before that, he was an activist in the South African Youth Congress.
Ntshangase was born on 1 April 1966[1] in Pongola in the north of the former Natal Province.[2] He was an activist in the South African Youth Congress and served as provincial chairperson of the ANC Youth League in KwaZulu-Natal from 1996 to 2000.[3]
While in his youth league office, Ntshangase was elected to the National Assembly in the 1999 general election; he joined the ANC's KwaZulu-Natal caucus. He remained in his seat until his death in February 2001. His seat was later filled by Albertina Luthuli.[4]
In 2008, Walter Gilbert Street in eThekwini was renamed Isaiah Ntshangase Road.[5] [6] Nathi Mthethwa addressed a memorial lecture held in his honour in 2019.