| Isabelle Debré | |
| Office: | Member of the French Senate for Hauts-de-Seine |
| Term Start: | 1 October 2004 |
| Term End: | 2017 |
| Birth Date: | 23 May 1957 |
| Birth Place: | Lisieux, France |
| Nationality: | French |
| Party: | The Republicans |
| Spouse: | Vincent Debré |
Isabelle Debré (born 23 May 1957 in Lisieux, Calvados) was a member of the Senate of France from 2004 to 2017. A member of The Republicans Party, she represented the Hauts-de-Seine department, in Île-de-France region.