| Isabel Riquelme | |
| Office: | First Lady of Chile |
| Term Label: | In role |
| Term Start: | February 17, 1817 |
| Term End: | January 28, 1823 |
| President: | Bernardo O'Higgins |
| Birth Name: | María Isabel Riquelme de la Barrera y Meza |
| Birth Place: | Chillán, Captaincy General of Chile, Spanish Empire |
| Death Place: | Lima, Peru |
| Spouse: | Manuel de Puga y Figueroa |
| Children: |
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| Parents: | Simón Riquelme de la Barrera y Goycochea María Mercedes de Mesa y Ulloa |
María Isabel Riquelme de la Barrera y Meza (1758 – April 21, 1839), was the mother of Chilean independence leader Bernardo O'Higgins. Isabel Riquelme was of Basque descent.[1]
She was born in Chillán, the second daughter of Simón Riquelme de la Barrera y Goycochea and of María Mercedes de Mesa y Ulloa. At the age of 19, she became pregnant by 58-year-old Ambrosio O'Higgins, Marquis of Osorno, future viceroy of Peru.
She married twice, first in 1780 to Félix Rodríguez y Rojas, by whom she had a daughter, Rosa Rodríguez y Riquelme (Chillán, August 30, 1781 – Lima, 1850). Her husband died in 1782, and she married her second husband, Manuel de Puga y Figueroa, by whom she had another daughter named Maria de las Nieves de Puga y Riquelme in 1793.