| Isaac Melville McCune | |
| Birth Date: | August 27, 1884 |
| Death Place: | Calgary, Alberta, Canada[1] |
| Birth Place: | McCune, Kansas, U.S.[2] |
| Office: | Member of the Legislative Assembly of Alberta |
| Constituency: | Gleichen |
| Term Start: | August 22, 1935 |
| Term End: | March 21, 1940 |
| Predecessor: | John Buckley |
| Successor: | Donald McKinnon |
| Party: | Social Credit |
| Occupation: | politician |
Isaac Melville McCune (August 27, 1884 – October 15, 1959) was a provincial politician from Alberta, Canada. He served as a member of the Legislative Assembly of Alberta from 1935 to 1940 sitting with the Social Credit caucus in government.
McCune ran for a seat to the Alberta Legislature as a Social Credit candidate in the electoral district of Gleichen in the 1935 Alberta general election. He defeated incumbent John Buckley and two other candidates by a wide margin to pick up the seat for his party.[3]
McCune ran for a second term in the 1940 Alberta general election. He was handily defeated by independent candidate Donald McKinnon finishing in second place out of three candidates.[4]