| Isaac Karo | |
| Birth Date: | 1458 |
| Birth Place: | Toledo, Spain |
| Death Date: | 1535 |
| Death Place: | probably Jerusalem |
| Nationality: | Spanish |
Isaac Karo (1458-1535) was a famous posek, preacher, Rosh Yeshiva, and physician. He was born in Toledo, Spain and probably died in Jerusalem. He was the uncle and teacher of Rabbi Joseph Karo, author of the Shulchan Aruch.
Rabbi Karo studied under Rabbi Isaac Canpanton in Toledo. Eventually, he moved to Lisbon in order to establish his own Yeshiva.
As a Spanish Jew, he was forcibly exiled from his homeland Spain after the signing of the Alhambra Decree in 1492 which expelled all Jews from the joint kingdom of Isabella I of Castile and Ferdinand II of Aragon. From Spain he immigrated to nearby Portugal, only to be expelled with the Jews of Portugal. While en route to Turkey all but one of his sons died. Although the details of Rabbi Karo's life afterwards are unclear, it is apparent that he lived Istanbul in Turkey.
In the year 1517, he completed his magnum opus, Toldot Yitzchak. In that year, he set out to Israel, but it is unclear whether he eventually reached Israel or did not. Some scholars write that he moved at this time to Damascus.