| Isaac Gyamfi | |
| Fullname: | Isaac Gyamfi |
| Birth Date: | 9 September 2000 |
| Birth Place: | Accra, Ghana |
| Position: | Central midfielder |
| Years1: | 2018–2020 |
| Caps1: | 9 |
| Goals1: | 0 |
| Years2: | 2020–2022 |
| Clubs2: | Tirana |
| Caps2: | 22 |
| Goals2: | 0 |
| Years3: | 2023 |
| Clubs3: | Medeama |
| Caps3: | 2 |
| Goals3: | 0 |
| Years4: | 2023 |
| Clubs4: | Energetik-BGU Minsk |
| Caps4: | 13 |
| Goals4: | 0 |
| Nationalyears1: | 2017 |
| Nationalteam1: | Ghana U17 |
| Nationalcaps1: | 5 |
| Nationalgoals1: | 0 |
| Club-Update: | 24 December 2023 |
Isaac Gyamfi (born 9 September 2000) is a Ghanaian footballer who plays as a central midfielder.