| Honorific-Prefix: | The Hon. |
| Isaac Burpee | |
| Smallimage: | Isaac Burpee.jpg |
| Constituency Mp: | City and County of St. John |
| Parliament: | Canadian |
| Predecessor: | John Hamilton Gray |
| Successor: | Charles Arthur Everett |
| Term Start: | 1872 |
| Term End: | 1885 |
| Birth Date: | 28 November 1825 |
| Birth Place: | Sheffield, New Brunswick |
| Death Place: | New York City, New York |
| Party: | Liberal |
| Cabinet: | Minister of Customs (1873-1878) Minister of Agriculture (Acting) (1876-1877) |
Isaac Burpee, (November 28, 1825 - March 1, 1885) was a Canadian merchant, entrepreneur, and politician.
Born in Sheffield, New Brunswick, the son of Isaac Burpee and Phoebe Coban, he was elected as a Liberal to the House of Commons of Canada in 1872 representing the riding of City and County of St. John, New Brunswick. He was the Minister of Customs and Minister of Agriculture (Acting). He served until his death in 1885.