| Isaac Applewhite House | |
| Coordinates: | 30.1433°N -96.2522°W |
| Map Label: | Isaac Applewhite House |
| Locmap Relief: | yes |
| Added: | February 20, 1985 |
| Mpsub: | Chappell Hill MRA |
| Refnum: | 85000342 |
| Designated Other1: | RTHL |
| Designated Other1 Date: | 1968 |
| Designated Other1 Number: | 8289 |
| Designated Other1 Num Position: | bottom |
Isaac Applewhite House is a historic house on Church Street in Chappell Hill, Texas.
It was built in 1852 and added to the National Register of Historic Places in 1985.