| Official Name: | Isa |
| Native Name: | Иса |
| Settlement Type: | Settlement |
| Pushpin Map: | Russia Amur Oblast#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Name1: | Amur Oblast |
| Subdivision Name3: | Selemdzhinsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +9:00 |
| Coordinates: | 51.75°N 132°W[1] |
Isa (Russian: Иса) is a rural locality (a settlement) in Isinsky Selsoviet of Selemdzhinsky District, Amur Oblast, Russia. The population was 433 as of 2018.[2] There are 11 streets.
Isa is located 294 km southwest of Ekimchan (the district's administrative centre) by road.[3]