Irwin McLean explained

Honorific Prefix:Professor
Irwin McLean
Birth Name:William Henry Irwin McLean
Birth Date:1963 1, df=yes
Birth Place:Ballymoney, County Antrim
Workplaces:University of Dundee
Alma Mater:Queen's University of Belfast (BSc, PhD, DSc)
Thesis Title:Electrophoretic and immunological analysis of proteins in the muscular dystrophies
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335992
Thesis Year:1988

William Henry Irwin McLean (born 1963) is an Irish geneticist who is emeritus professor of genetic medicine, at the School of Life Sciences, University of Dundee.[1] [2] [3] [4] [5]

Education

McLean was educated at Queen's University of Belfast where he was awarded a Bachelor of Science degree with honours in microbiology in 1985 followed by a PhD in 1988 for electrophoretic and immunological analysis of proteins involved in muscular dystrophy.[6]

Research

The McLean Lab investigates genetic disorders that affect the cells and tissues of the epithelium[7] [8] [9] [10] [11] [12] and is funded by the Medical Research Council (MRC)[13] and the Wellcome Trust.[14]

Awards and honours

McLean was elected a fellow of the Royal Society in 2014. His nomination reads:

Notes and References

  1. 16550169. 2006. Palmer. C. N.. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics. 38. 4. 441–446. Irvine. A. D.. Terron-Kwiatkowski. A. Zhao. Y. Liao. H. Lee. S. P.. Goudie. D. R.. Sandilands. A. Campbell. L. E.. Smith. F. J.. O'Regan. G. M.. Watson. R. M.. Cecil. J. E.. Bale. S. J.. Compton. J. G.. Digiovanna. J. J.. Fleckman. P. Lewis-Jones. S. Arseculeratne. G. Sergeant. A. Munro. C. S.. El Houate. B. McElreavey. K. Halkjaer. L. B.. Bisgaard. H. Mukhopadhyay. S. McLean. W. H.. Irwin McLean. 10.1038/ng1767. 2500278.
  2. 16444271. 2006. Smith. F. J.. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nature Genetics. 38. 3. 337–342. Irvine. A. D.. Terron-Kwiatkowski. A. Sandilands. A. Campbell. L. E.. Zhao. Y. Liao. H. Evans. A. T.. Goudie. D. R.. Lewis-Jones. S. Arseculeratne. G. Munro. C. S.. Sergeant. A. O'Regan. G. Bale. S. J.. Compton. J. G.. Digiovanna. J. J.. Presland. R. B.. Fleckman. P. McLean. W. H.. Irwin McLean. 10.1038/ng1743. 21948747.
  3. 23154627. 2012. McLean. W. H.. Heritable filaggrin disorders: The paradigm of atopic dermatitis. The Journal of Investigative Dermatology. 132. E1. E20–E21. Irvine. A. D.. 10.1038/skinbio.2012.6. free. 2262/74868. free.
  4. 16815158. 2006. Weidinger. S. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. The Journal of Allergy and Clinical Immunology. 118. 1. 214–219. Illig. T. Baurecht. H. Irvine. A. D.. Rodriguez. E. Diaz-Lacava. A. Klopp. N. Wagenpfeil. S. Zhao. Y. Liao. H. Lee. S. P.. Palmer. C. N.. Jenneck. C. Maintz. L. Hagemann. T. Behrendt. H. Ring. J. Nothen. M. M.. McLean. W. H.. Novak. N. 10.1016/j.jaci.2006.05.004.
  5. Book: Molecular Dermatology: Methods and Protocols . 961. 10.1007/978-1-62703-227-8. 9781627032261. Methods in Molecular Biology. 2013. Has. Cristina. Sitaru. Cassian. 21781092.
  6. PhD . William Henry Irwin. McLean . Electrophoretic and immunological analysis of proteins in the muscular dystrophies . Queen's University of Belfast . 1988 . Irwin McLean.
  7. http://www.lifesci.dundee.ac.uk/groups/irwin-mclean/ Research in the McLean Lab
  8. 17291859. 2007. Nomura. T. Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. The Journal of Allergy and Clinical Immunology. 119. 2. 434–440. Sandilands. A. Akiyama. M. Liao. H. Evans. A. T.. Sakai. K. Ota. M. Sugiura. H. Yamamoto. K. Sato. H. Palmer. C. N.. Smith. F. J.. McLean. W. H.. Shimizu. H. 10.1016/j.jaci.2006.12.646.
  9. 18307574. 2008. Basu. K. Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults. Allergy. 63. 9. 1211–1217. Palmer. C. N.. Lipworth. B. J.. Irwin Mclean. W. H.. Irwin McLean. Terron-Kwiatkowski. A. Zhao. Y. Liao. H. Smith. F. J.. Mitra. A. Mukhopadhyay. S. 10.1111/j.1398-9995.2008.01660.x. 8105444.
  10. 17531295. 2007. Palmer. C. N.. Filaggrin null mutations are associated with increased asthma severity in children and young adults. The Journal of Allergy and Clinical Immunology. 120. 1. 64–68. Ismail. T. Lee. S. P.. Terron-Kwiatkowski. A. Zhao. Y. Liao. H. Smith. F. J.. McLean. W. H.. Mukhopadhyay. S. 10.1016/j.jaci.2007.04.001. free.
  11. 18325573. 2008. Henderson. J. The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study. The Journal of Allergy and Clinical Immunology. 121. 4. 872–877.e9. Northstone. K. Lee. S. P.. Liao. H. Zhao. Y. Pembrey. M. Mukhopadhyay. S. Smith. G. D.. Palmer. C. N.. McLean. W. H.. Irvine. A. D.. 10.1016/j.jaci.2008.01.026. free.
  12. 18578563. 2504043. 2008. Bisgaard. H. Gene-environment interaction in the onset of eczema in infancy: Filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLOS Medicine. 5. 6. e131. Simpson. A. Palmer. C. N.. Bønnelykke. K. McLean. I. Mukhopadhyay. S. Pipper. C. B.. Halkjaer. L. B.. Lipworth. B. Hankinson. J. Woodcock. A. Custovic. A. 10.1371/journal.pmed.0050131. free.
  13. http://gtr.rcuk.ac.uk/person/ACD6437C-C203-4D72-B0AF-9A502AB5C3BF UK Government research grants awarded to Irwin McLean
  14. Web site: Wellcome Trust strategic awards 2013 . 17 August 2014 . 26 April 2016 . https://web.archive.org/web/20160426035213/http://www.wellcome.ac.uk/Funding/Biomedical-science/Funded-projects/Awards-made/Strategic-Awards/index.htm . dead .

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