| Iriondo Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of Iriondo in Argentina |
| Coordinates: | -32.8167°N -85°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Santa Fe |
| Seat Type: | Head town |
| Seat: | Cañada de Gómez |
| Unit Pref: | Metric |
| Area Total Km2: | 3184 |
| Population Total: | 65486 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
The Iriondo Department (in Spanish, Departamento Iriondo) is an administrative subdivision (departamento) of the . It is located in the south of the province. It limits with the departments of San Jerónimo in the north, San Lorenzo in the east, Caseros in the south, and Belgrano in the west. It is one of only three departments in Santa Fe that do not border another province.
The department has a population of over 65,000 inhabitants. Its head town and most populated urban center is Cañada de Gómez (population 30,000). Other cities and towns are Bustinza, Carrizales, Classon, Correa, Lucio V. López, Oliveros, Pueblo Andino, Salto Grande, Serodino, Totoras, and Villa Eloísa.