Ipratropium bromide/salbutamol explained

Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).

Common side effects include sore throat, muscle cramps, and nausea. Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections. Safety in pregnancy is unclear.[2]

The combination was approved for medical use in the United States in 1996.[3] It is available as a generic medication.[4] In 2021, it was the 151st most commonly prescribed medication in the United States, with more than 3million prescriptions.[5] [6]

Medical uses

Ipratropium bromide/salbutamol can be used for the treatment of COPD and asthma.[7]

Society and culture

Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to depletion of the ozone layer.[8]

Notes and References

  1. Gordon J, Panos RJ . Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease . Expert Opinion on Drug Metabolism & Toxicology . 6 . 3 . 381–92 . March 2010 . 20163324 . 10.1517/17425251003649549 . 31806856 .
  2. Web site: Albuterol / ipratropium Use During Pregnancy . Drugs.com . 19 April 2019 .
  3. Web site: Ipratropium and Albuterol - FDA prescribing information, side effects and uses . Drugs.com . 18 April 2019 . en.
  4. Book: British national formulary : BNF 76. 2018. Pharmaceutical Press. 9780857113382. 247. 76.
  5. Web site: The Top 300 of 2021 . ClinCalc . 14 January 2024 . 15 January 2024 . https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx . live .
  6. Web site: Albuterol; Ipratropium - Drug Usage Statistics . ClinCalc . 14 January 2024 .
  7. Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, Manuel RC, Schlenker-Herceg R, Bleecker ER . Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial . BMC Pulmonary Medicine . 16 . 1 . 65 . April 2016 . 27130202 . 4851785 . 10.1186/s12890-016-0223-3 . free .
  8. Web site: 3 November 2018 . Phase Out of Combivent Inhalation Aerosol - Questions and Answers . FDA .

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