Ipidacrine Explained

Ipidacrine (Neiromidin) is a drug first synthesized by the National Research Center for Biologically Active Compounds in the Russian Federation. This compound is a modification of the older drug tacrine (Cognex).^[1]

Ipidacrine is a reversible acetylcholinesterase inhibitor used in memory disorders of different origins.^{[2] [3] [4]}

Ipidacrine directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels. Ipidacrine enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.^[5]

Notes and References

1. Kojima J, Onodera K, Ozeki M, Nakayarna K . Ipidacrine (NIK-247): A Review of Multiple Mechanisms as an Antidementia Agent . 1998 . CNS Drug Reviews . 4 . 3 . 247–259 . 10.1111/j.1527-3458.1998.tb00067.x . free .
2. Damulin IV, Stepkina DA, Lokshina AB . [Neuromidin in mixed vascular and Alzheimer's dementia] . Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova . 111 . 2 . 40–3 . 2011 . 21350422 .
3. Pustokhanova LV, Morozova EM . [Cognitive disorders in the early rehabilitation period of ischemic stroke and possibilities of their treatment with neuromidin] . Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova . 111 . 4 Pt 2 . 23–7 . 2011 . 23120773 .
4. Onodera K, Kojima J, Wachi M . Ipidacrine (NIK-247), a novel antidementia, rapidly enters the brain and improves scopolamine-induced amnesia in rats during the Morris water maze task . Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology . 18 . 2 . 33–7 . April 1998 . 9656230 .
5. Web site: Neiromidin Product Information . 2013-05-30 . https://web.archive.org/web/20130613124711/http://olainfarm.lv/en/prescription-drugs/neiromidin-3 . 2013-06-13 . dead .