| State: | IA |
| Type: | IA 1926 |
| Route: | 59 |
| Established: | 1920 |
| Decommissioned: | 1934 |
| Previous Type: | US |
| Previous Route: | 59 |
| Next Type: | IA |
| Next Route: | 60 |
Iowa Highway 59 (Iowa 59) was the designation of a state highway in Iowa that ran from the Missouri state line near Cincinnati to the Minnesota state line near Chester. Iowa 59 was in existence for fourteen years—from 1920 to 1934. Today, the route is related to the following highways: