Ion transporter superfamily explained

The ion transporter (IT) superfamily is a superfamily of secondary carriers that transport charged substrates.^{[1] [2]}

Families

As of early 2016, the currently recognized and functionally defined families that make up the IT superfamily include:

• 2.A.8 - The Gluconate:H⁺ Symporter (GntP) Family
• 2.A.11 - The Citrate-Mg²⁺:H⁺ (CitM) Citrate-Ca²⁺:H⁺ (CitH) Symporter (CitMHS) Family
• 2.A.13 - The C₄-Dicarboxylate Uptake (Dcu) Family
• 2.A.14 - The Lactate Permease (LctP) Family
• 2.A.34 - The NhaB Na⁺:H⁺ Antiporter (NhaB) Family
• 2.A.35 - The NhaC Na⁺:H⁺ Antiporter (NhaC) Family
• 2.A.45 - The Arsenite-Antimonite (ArsB) Efflux Family
• 2.A.47 - The Divalent Anion:Na⁺ Symporter (DASS) Family
• 2.A.61 - The C₄-dicarboxylate Uptake C (DcuC) Family
• 2.A.62 - The NhaD Na⁺:H⁺ Antiporter (NhaD) Family
• 2.A.68 - The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
• 2.A.94 - The Phosphate Permease (Pho1) Family
  • 2.A.101 - The Malonate Uptake (MatC) Family 2.A.111 - The Na⁺/H⁺ Antiporter-E (NhaE) Family
• 2.A.118 - The Basic Amino Acid Antiporter (ArcD) Family

See also

• Ion transporters
• Sodium-Proton antiporter
• Arsenite-Antimonite efflux
• Amino acid transporter
• Solute carrier family
• Transporter Classification Database
• Membrane protein

Notes and References

1. Prakash S, Cooper G, Singhi S, Saier MH . The ion transporter superfamily . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1618 . 1 . 79–92 . December 2003 . 14643936 . 10.1016/j.bbamem.2003.10.010 . free .
2. Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier MH . Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments . Journal of Molecular Microbiology and Biotechnology . 21 . 3–4 . 83–96 . 2011-01-01 . 22286036 . 3290041 . 10.1159/000334611 .