Iodocholesterol Explained

Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (¹³¹I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical.^{[1] [2]} When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism,^[3] pheochromocytoma, and adrenal remnants following total adrenalectomy.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 692–.
2. Book: Clark OH, ((American Cancer Society)) . Endocrine Tumors. 2003. PMPH-USA. 978-1-55009-134-2. 124–.
3. Fischer M, Rosenbach EA, Glaser B, Stokar J . NP-59 Scintigraphy for Primary Aldosteronism Lateralization in a Patient With Polycystic Kidney Disease . English . AACE Clinical Case Reports . 9 . 3 . 97–98 . 2023-02-24 . 37251975 . 10213608 . 10.1016/j.aace.2023.02.006 . 257212197 .