| John II Mavrocordatos | |
| Succession: | Prince of Moldavia |
| Reign1: | 29 June 1743 – May 1747 |
| Predecessor1: | Constantine Mavrocordatos |
| Successor1: | Grigore II Ghica |
| Spouse: | Maria Giuliano, Sultana Mano |
| Issue: | Alexander II Mavrocordatos |
| House: | Mavrocordatos |
| House-Type: | Dynasty |
| Father: | Nicholas Mavrocordatos |
| Birth Date: | 12 March 1712 |
| Birth Place: | Istanbul |
| Death Date: | 29 July 1747 |
| Death Place: | Istanbul |
| Religion: | Orthodox |
John II Mavrocordatos (12 March 1712 – 29 July 1747) was a Phanariote who served as prince of Moldavia from 1743 to 1747.
Younger son of Nicholas Mavrocordatos, he remained in the shadow of his elder brother, Constantine. He replaced the latter in Moldavia on the occasion of one of his many changes of office as Hospodar of Moldavia from July 1743 to May 1747.
John II Mavrocordatos married successively Maria Giuliano and Sultana Mano, of whom he had: