| Ioan Grigore Ghica | |
| Minister of Foreign Affairs of Principality of Romania | |
| Term Start: | 17 October 1865 |
| Term End: | 10 February 1866 |
| Predecessor: | Alexandru Cantacuzino |
| Successor: | Nicolae Rosetti-Bălănescu |
| Office2: | Ministry of War of Principality of Romania |
| Term Start2: | 19 July 1861 |
| Term End2: | 29 September 1862 |
| Predecessor2: | office established |
| Successor2: | Ion Emanoil Florescu |
| Term Start3: | 11 May 1866 |
| Term End3: | 5 August 1866 |
| Predecessor3: | Dimitrie Lecca |
| Successor3: | Nicolae Haralambie |
| Birth Date: | 10 December 1830 |
| Birth Place: | Iași, Moldavia |
| Death Place: | Saint Petersburg, Russian Empire |
| Father: | Grigore Alexandru Ghica |
| Spouse: | Alexandrina Moret de Blaremberg |
| Children: | Vladimir Ghika Dimitrie I. Ghika |
Prince Ioan Grigore Ghica (10 December 1830 - 21 March 1881) was a Romanian politician who served as the Minister of Foreign Affairs of Principality of Romania from 29 September 1862 to 29 August 1863. He also served as the Minister of War in two terms from 19 July 1861 until 29 September 1862, and from 11 May 1866 until 5 August 1866. Ioan Grigore Ghica also served as the ambassador to Istanbul, Vienna, Rome, and Saint Petersburg.
He was born in Iași, the son of the last Prince of Moldavia, Grigore Alexandru Ghica. He married Alexandrina Moret de Blaremberg, with whom he had five children, including Vladimir Ghika and Dimitrie I. Ghika.