Intramyocellular lipids explained

Intramyocellular lipids (or IMCL) are fats stored in droplets in muscle cells. They provide an important energy source for working muscle. During exercise, a large amount of circulating free fatty acids are directed into muscle cells for energy; during rest, incoming fatty acids are instead stored in the muscle cell as triglycerides for later burning.^[1] However, an increase in muscle insulin resistance, caused by obesity, diabetes mellitus type 2, and metabolic syndrome, will result in an excess accumulation of intramyocellular lipids.^{[2] [3]}

See also

Insulin glargine

External links

• Intramyocellular lipid content in human skeletal muscle

Notes and References

1. Schrauwen-Hinderling VB, van Loon LJ, Koopman R, Nicolay K, Saris WH, Kooi ME . Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle. Journal of Applied Physiology. December 1, 2003. 95. 6. 2328–2332. 10.1152/japplphysiol.00304.2003. 12923116.
2. Guo ZK . Intramyocellular lipid kinetics and insulin resistance . Lipids Health Dis . 6 . 18 . 2007 . 17650308 . 1971250 . 10.1186/1476-511X-6-18 . free .
3. Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti S, Granzotto M, Vettor R, Camastra S, Ferrannini E . Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion . Diabetes . 51 . 1 . 144–51 . 2002 . 11756334 . 10.2337/diabetes.51.1.144 . free .