IgA pemphigus explained

IgA pemphigus
Field:	Dermatology

IgA pemphigus is a subtype of pemphigus with two distinct forms:

• Subcorneal pustular dermatosis (also known as Sneddon–Wilkinson disease and pustulosis subcornealis)^[1] is skin condition that is a rare, chronic, recurrent, pustular eruption characterized histopathologically by subcorneal pustules that contain abundant neutrophils.^{[2] [3]} This is distinct from and not to be confused with subcorneal pustular dermatosis type of IgA pemphigus. Sneddon's syndrome, also known as Ehrmann-Sneddon syndrome, is also a different syndrome.^[4]
• Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.^[3]

History

Early descriptions were made by Darrell Wilkinson, a British dermatologist.^[5]

See also

• Pemphigus
• List of target antigens in pemphigus
• List of conditions caused by problems with junctional proteins
• List of immunofluorescence findings for autoimmune bullous conditions

Notes and References

1. Web site: RESERVED. INSERM US14 -- ALL RIGHTS. Orphanet: Subcorneal pustular dermatosis. www.orpha.net. 8 March 2017. en.
2. Book: Fitzpatrick's dermatology in general medicine.. 2003. McGraw-Hill. New York, NY [u.a.]. 978-0-07-138076-8. 625. 6th. Irwin M. Freedberg. etal.
3. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
4. Web site: Berlit. Peter. Sneddon's Syndrome. Orphanet.
5. Web site: Munks Roll Details for Peter Edward Darrell Sheldon Wilkinson. munksroll.rcplondon.ac.uk. 2017-11-10.