LASIK explained

LASIK
Field:Ophthalmology, optometry

LASIK or Lasik (laser-assisted in situ keratomileusis), commonly referred to as laser eye surgery or laser vision correction, is a type of refractive surgery for the correction of myopia, hyperopia, and astigmatism. LASIK surgery is performed by an ophthalmologist who uses a femtosecond laser or a microkeratome to create a corneal flap to expose the corneal stroma and then an excimer laser to reshape the corneal stroma in order to improve visual acuity.[1] [2]

LASIK is very similar to another surgical corrective procedure, photorefractive keratectomy (PRK), and LASEK. All represent advances over radial keratotomy in the surgical treatment of refractive errors of vision. For patients with moderate to high myopia or thin corneas which cannot be treated with LASIK and PRK, the phakic intraocular lens is an alternative.[3] [4]

As of 2018, roughly 9.5 million Americans have had LASIK[5] [6] and, globally, between 1991 and 2016, more than 40 million procedures were performed.[7] [8] However, the procedure seemed to be a declining option as of 2015.[9]

Process

The planning and analysis of corneal reshaping techniques such as LASIK have been standardized by the American National Standards Institute, an approach based on the Alpins method of astigmatism analysis.The FDA website on LASIK states,

"Before undergoing a refractive procedure, you should carefully weigh the risks and benefits based on your own personal value system, and try to avoid being influenced by friends that have had the procedure or doctors encouraging you to do so."[10]

The procedure involves creating a thin flap on the eye, folding it to enable remodeling of the tissue beneath with a laser and repositioning the flap.

Preoperative procedures

Pre-operative examination and education

In the United States, the FDA has approved LASIK for age 18 or 22 and over because the vision has to stabilize. More importantly the patient's eye prescription should be stable for at least one year prior to surgery.The patient may be examined with pupillary dilation and education given prior to the procedure. Before the surgery, the patient's corneas are examined with a pachymeter to determine their thickness, and with a topographer, or corneal topography machine, to measure their surface contour. Using low-power lasers, a topographer creates a topographic map of the cornea. The procedure is contraindicated if the topographer finds difficulties such as keratoconus The preparatory process also detects astigmatism and other irregularities in the shape of the cornea. Using this information, the surgeon calculates the amount and the location of corneal tissue to be removed. The patient is prescribed and self-administers an antibiotic beforehand to minimize the risk of infection after the procedure and is sometimes offered a short acting oral sedative medication as a pre-medication. Prior to the procedure, anaesthetic eye drops are instilled. Factors that may rule out LASIK for some patients include large pupils, thin corneas and extremely dry eyes.[11]

Operative procedure

LASIK permanently changes the shape of the cornea, the clear covering of the front of the eye, using an excimer laser. A mechanical microkeratome (a blade device) or a laser keratome (femtosecond laser) is used to cut a flap in the cornea. A hinge is left at one end of this flap. The flap is folded back revealing the corneal stroma, the middle section of the cornea. Pulses from a computer-controlled laser (excimer laser) vaporize a portion of the stroma and the flap is replaced.[1]

Performing the laser ablation in the deeper corneal stroma provides for more rapid visual recovery and less pain than the earlier technique, photorefractive keratectomy (PRK).[12]

Postoperative care

Patients are usually given a course of antibiotic and anti-inflammatory eye drops. These are continued in the weeks following surgery. Patients are told to rest and are given dark eyeglasses to protect their eyes from bright lights and occasionally protective goggles to prevent rubbing of the eyes when asleep and to reduce dry eyes. They also are required to moisturize the eyes with preservative-free tears and follow directions for prescription drops. Occasionally after the procedure a bandage contact lens is placed to aid the healing, and typically removed after 3–4 days. Patients should be adequately informed by their surgeons of the importance of proper post-operative care to minimize the risk of complications.[13]

Wavefront-guided

Wavefront-guided LASIK is a variation of LASIK surgery in which, rather than applying a simple correction of only long/short-sightedness and astigmatism (only lower order aberrations as in traditional LASIK), an ophthalmologist applies a spatially varying correction, guiding the computer-controlled excimer laser with measurements from a wavefront sensor. The goal is to achieve a more optically perfect eye, though the result still depends on the physician's success at predicting changes that occur during healing and other factors that may have to do with the regularity/irregularity of the cornea and the axis of any residual astigmatism. Another important factor is whether the excimer laser can correctly register eye position in 3 dimensions, and to track the eye in all the possible directions of eye movement. If a wavefront guided treatment is performed with less than perfect registration and tracking, pre-existing aberrations can be worsened. In older patients, scattering from microscopic particles (cataract or incipient cataract) may play a role that outweighs any benefit from wavefront correction.[14] [15] [16] [17]

When treating a patient with preexisting astigmatism, most wavefront-guided LASIK lasers are designed to treat regular astigmatism as determined externally by corneal topography. In patients who have an element of internally induced astigmatism, therefore, the wavefront-guided astigmatism correction may leave regular astigmatism behind (a cross-cylinder effect). If the patient has preexisting irregular astigmatism, wavefront-guided approaches may leave both regular and irregular astigmatism behind. This can result in less-than-optimal visual acuity compared with a wavefront-guided approach combined with vector planning, as shown in a 2008 study.[18]

The "leftover" astigmatism after a purely surface-guided laser correction can be calculated beforehand, and is called ocular residual astigmatism (ORA). ORA is a calculation of astigmatism due to the noncorneal surface (internal) optics. The purely refraction-based approach represented by wavefront analysis actually conflicts with corneal surgical experience developed over many years.

The pathway to "super vision" thus may require a more customized approach to corneal astigmatism than is usually attempted, and any remaining astigmatism ought to be regular (as opposed to irregular), which are both fundamental principles of vector planning overlooked by a purely wavefront-guided treatment plan. This was confirmed by the 2008 study mentioned above, which found a greater reduction in corneal astigmatism and better visual outcomes under mesopic conditions using wavefront technology combined with vector analysis than using wavefront technology alone, and also found equivalent higher-order aberrations (see below). Vector planning also proved advantageous in patients with keratoconus.[19]

No good data can be found that compare the percentage of LASIK procedures that employ wavefront guidance versus the percentage that do not, nor the percentage of refractive surgeons who have a preference one way or the other. Wavefront technology continues to be positioned as an "advance" in LASIK with putative advantages;[20] [21] [22] [23] however, it is clear that not all LASIK procedures are performed with wavefront guidance.[24]

Still, surgeons claim patients are generally more satisfied with this technique than with previous methods, particularly regarding lowered incidence of "halos," the visual artifact caused by spherical aberration induced in the eye by earlier methods. A meta-analysis of eight trials showed a lower incidence of these higher order aberrations in patients who had wavefront-guided LASIK compared to non-wavefront-guided LASIK.[25] Based on their experience, the United States Air Force has described WFG-Lasik as giving "superior vision results".[26]

Topography-assisted

Topography-assisted LASIK is intended to be an advancement in precision and reduce night-vision side effects. The first topography-assisted device received FDA approval September 13, 2013.[27] [28]

History

Barraquer's early work

In the 1950s, the microkeratome and keratomileusis technique were developed in Bogotá, Colombia, by the Spanish ophthalmologist José Barraquer. In his clinic, he would cut thin (one hundredth of a mm thick) flaps in the cornea to alter its shape. Barraquer also investigated how much of the cornea had to be left unaltered in order to provide stable long-term results.[29]

Laser refractive surgery

In 1980, Rangaswamy Srinivasan, Samuel E. Blum and James J. Wynne at the IBM Research laboratory, discovered that an ultraviolet excimer laser could etch living tissue, with precision and with no thermal damage to the surrounding area. The phenomenon was termed "ablative photo-decomposition" (APD).[30] [31] Five years later, in 1985, Steven Trokel at the Edward S. Harkness Eye Institute, Columbia University in New York City, published his work using the excimer laser in radial keratotomy. He wrote,

"The central corneal flattening obtained by radial diamond knife incisions has been duplicated by radial laser incisions in 18 enucleated human eyes. The incisions, made by 193 nm far-ultraviolet light radiation emitted by the excimer laser, produced corneal flattening ranging from 0.12 to 5.35 diopters. Both the depth of the corneal incisions and the degree of central corneal flattening correlated with the laser energy applied. Histopathology revealed the remarkably smooth edges of the laser incisions."[32] Together with his colleagues, Charles Munnerlyn and Terry Clapham, Trokel founded VISX USA inc.[33] Marguerite B. MacDonald MD performed the first human VISX refractive laser eye surgery in 1989.[34]

Patent

A number of patents have been issued for several techniques related to LASIK. Rangaswamy Srinivasan and James Wynne filed a patent application on the ultraviolet excimer laser, in 1986, issued in 1988.[35] In 1989, Gholam A. Peyman was granted a US patent for using an excimer laser to modify corneal curvature.[36] It was,

"A method and apparatus for modifying the curvature of a live cornea via use of an excimer laser. The live cornea has a thin layer removed therefrom, leaving an exposed internal surface thereon. Then, either the surface or thin layer is exposed to the laser beam along a predetermined pattern to ablate desired portions. The thin layer is then replaced onto the surface. Ablating a central area of the surface or thin layer makes the cornea less curved, while ablating an annular area spaced from the center of the surface or layer makes the cornea more curved. The desired predetermined pattern is formed by use of a variable diaphragm, a rotating orifice of variable size, a movable mirror or a movable fiber optic cable through which the laser beam is directed towards the exposed internal surface or removed thin layer."The patents related to so-called broad-beam LASIK and PRK technologies were granted to US companies including Visx and Summit during 1990–1995 based on the fundamental US patent issued to IBM (1988) which claimed the use of UV laser for the ablation of organic tissues.

Implementation in the U.S.

The LASIK technique was implemented in the U.S. after its successful application elsewhere. The Food and Drug Administration (FDA) commenced a trial of the excimer laser in 1989. The first enterprise to receive FDA approval to use an excimer laser for photo-refractive keratectomy was Summit Technology (founder and CEO, Dr. David Muller).[37] In 1992, under the direction of the FDA, Greek ophthalmologist Ioannis Pallikaris introduced LASIK to ten VISX centers. In 1998, the "Kremer Excimer Laser", serial number KEA 940202, received FDA approval for its singular use for performing LASIK.[38] Subsequently, Summit Technology was the first company to receive FDA approval to mass manufacture and distribute excimer lasers. VISX and other companies followed. Pallikaris suggested a flap of cornea could be raised by microkeratome prior to the performing of PRK with the excimer laser. The addition of a flap to PRK became known as LASIK.

Recent years

The procedure seems to be a declining option for many in the United States, dropping more than 50 percent, from about 1.5 million surgeries in 2007 to 604,000 in 2015, according to the eye-care data source Market Scope.[39] A study determined the frequency with which LASIK was searched on Google from 2007 to 2011.[40] Within this time frame, LASIK searches declined by 40% in the United States. Countries such as the U.K. and India also showed a decline, 22% and 24% respectively. Canada, however, showed an increase in LASIK searches by 8%. This decrease in interest can be attributed to several factors: the emergence of refractive cataract surgery, the economic recession in 2008, and unfavorable media coverage from the FDA's 2008 press release on LASIK.

Effectiveness

In 2006, the British National Health Service's National Institute for Health and Clinical Excellence (NICE) considered evidence of the effectiveness and the potential risks of the laser surgery stating "current evidence suggests that photorefractive (laser) surgery for the correction of refractive errors is safe and effective for use in appropriately selected patients. Clinicians undertaking photorefractive (laser) surgery for the correction of refractive errors should ensure that patients understand the benefits and potential risks of the procedure. Risks include failure to achieve the expected improvement in unaided vision, development of new visual disturbances, corneal infection and flap complications. These risks should be weighed against those of wearing spectacles or contact lenses."[41] The FDA reports "The safety and effectiveness of refractive procedures has not been determined in patients with some diseases."[42]

Satisfaction

Surveys of LASIK surgery find rates of patient satisfaction between 92 and 98 percent.[43] [44] [45] In March 2008, the American Society of Cataract and Refractive Surgery published a patient satisfaction meta-analysis of over 3,000 peer-reviewed articles from international clinical journals. Data from a systematic literature review conducted from 1988 to 2008, consisting of 309 peer-reviewed articles about "properly conducted, well-designed, randomized clinical trials" found a 95.4 percent patient satisfaction rate among LASIK patients.[46]

A 2017 study claims that overall, preoperative symptoms decreased significantly, and visual acuity excelled. A meta-analysis discovered that 97% of patients achieved uncorrected visual acuity (UCVA) of 20/40, while 62% achieved 20/20.[47]

Dissatisfaction

Some people with poor outcomes from LASIK surgical procedures report a significantly reduced quality of life because of vision problems or pain associated with the surgery. A small percentage of patients may need further surgery because their condition is over- or under-corrected. Some patients need to wear contact lenses or glasses even after treatment.[48]

The most common reason for dissatisfaction in LASIK patients is chronic severe dry eye. Independent research indicates 95% of patients experience dry eye in the initial post-operative period. This number has been reported to up to 60% after one month. Symptoms begin to improve in the vast majority of patients in the 6 to 12 months following the surgery.[49] However, 30% of post-LASIK referrals to tertiary ophthalmology care centers have been shown to be due to chronic dry eye.[50] [51]

Morris Waxler, a former FDA official who was involved in the approval of LASIK, subsequently criticized its widespread use. In 2010, Waxler made media appearances and claimed that the procedure had a failure rate greater than 50%. The FDA responded that Waxler's information was "filled with false statements, incorrect citations" and "mischaracterization of results".[52]

A 2016 study indicates that the prevalence of complications from LASIK are higher than indicated, with the study indicating many patients experience glare, halos or other visual symptoms.[53] Forty-three percent of participants in a 2017 study reported new visual symptoms they had not experienced before.

Presbyopia

A type of LASIK, known as presbyLasik, may be used in presbyopia. Results are, however, more variable and some people have a decrease in visual acuity.[54]

Risks

Higher-order aberrations

Higher-order aberrations are visual problems that require special testing for diagnosis and are not corrected with normal spectacles (eyeglasses). These aberrations include 'starbursts', 'ghosting', 'halos' and others.[55] Some patients describe these symptoms post-operatively and associate them with the LASIK technique including the formation of the flap and the tissue ablation.[56]

Others propose that higher-order aberrations are present preoperatively.[57] They can be measured in micrometers (μm) whereas the smallest laser-beam size approved by the FDA is about 1000 times larger, at 0.65 mm.In situ keratomileusis effected at a later age increases the incidence of corneal higher-order wavefront aberrations.[58] [59] These factors demonstrate the importance of careful patient selection for LASIK treatment.

Dry eyes

95% of patients report dry-eye symptoms after LASIK.[60] Although it is usually temporary, it can develop into chronic and severe dry eye syndrome. Quality of life can be severely affected by dry-eye syndrome.[61]

Underlying conditions with dry eye such as Sjögren's syndrome are considered contraindications to Lasik.[62]

Treatments include artificial tears, prescription tears, and punctal occlusion. Punctal occlusion is accomplished by placing a collagen or silicone plug in the tear duct, which normally drains fluid from the eye. Some patients complain of ongoing dry-eye symptoms despite such treatments and the symptoms may be permanent.[63]

Halos

Some post-LASIK patients see halos and starbursts around bright lights at night.

Complications due to LASIK have been classified as those that occur due to preoperative, intraoperative, early postoperative, or late postoperative sources:[64] According to the UK National Health Service, complications occur in fewer than 5% of cases.

Other complications

FDA's position

In October 2009, the FDA, the National Eye Institute (NEI), and the Department of Defense (DoD) launched the LASIK Quality of Life Collaboration Project (LQOLCP) to help better understand the potential risk of severe problems that can result from LASIK[82] in response to widespread reports of problems experienced by patients after LASIK laser eye surgery.[83] This project examined patient-reported outcomes with LASIK (PROWL). The project consisted of three phases: pilot phase, phase I, phase II (PROWL-1) and phase III (PROWL-2). The last two phases were completed in 2014.

The results of the LASIK Quality of Life Study were published in October 2014.

The FDA's director of the Division of Ophthalmic Devices, said about the LASIK study "Given the large number of patients undergoing LASIK annually, dissatisfaction and disabling symptoms may occur in a significant number of patients".[84] Also in 2014, FDA published an article highlighting the risks and a list of factors and conditions individuals should consider when choosing a doctor for their refractive surgery.[85]

Contraindications

Not everyone is eligible to receive LASIK. Severe keratoconus or thin corneas may disqualify patients from LASIK, though other procedures may be viable options. Those with Fuchs' corneal endothelial dystrophy, corneal epithelial basement membrane dystrophy, retinal tears, autoimmune diseases, severe dry eyes, and significant blepharitis should be treated before consideration for LASIK. Women who are pregnant or nursing are generally not eligible to undergo LASIK.[86]

People with large pupils (e.g. due to taking medications or in the younger age group) may be particularly prone to symptoms such as glare, halos, starbursts, and ghost images (double vision) in dim light after surgery. Because the laser can only work on the inner section of the cornea, the outer rim is left unaffected. In dim lighting, a patient's pupils dilate and may be predisposed to optic aberrations due to refractive asynchrony of the two regions with regards to the incoming light.[87]

Further research

Since 1991, there have been further developments such as faster lasers; larger spot areas; bladeless flap incisions; intraoperative corneal pachymetry; and "wavefront-optimized" and "wavefront-guided" techniques which were introduced by the University of Michigan's Center for Ultrafast Optical Science. The goal of replacing standard LASIK in refractive surgery is to avoid permanently weakening the cornea with incisions and to deliver less energy to the surrounding tissues. More recently, techniques like Epi-Bowman Keratectomy have been developed that avoid touching the epithelial basement membrane or Bowman's layer.[88]

Experimental techniques

Comparison to photorefractive keratectomy

A systematic review that compared PRK and LASIK concluded that LASIK has shorter recovery time and less pain. The two techniques after a period of one year have similar results.[94]

A 2017 systematic review found uncertainty in visual acuity, but found that in one study, those receiving PRK were less likely to achieve a refractive error, and were less likely to have an over-correction than compared to LASIK.[95]

External links

Notes and References

  1. Web site: Health . Center for Devices and Radiological . LASIK . fda.gov . FDA . 15 August 2024 . en . 13 June 2023.
  2. News: Medical Mystery: Preparation for surgery revealed cause of deteriorating eyesight. . Peter . Finn . 20 December 2012 .
  3. Lovisolo CF, Reinstein DZ . Phakic intraocular lenses . Survey of Ophthalmology . 50 . 6 . 549–87 . Nov–Dec 2005 . 16263370 . 10.1016/j.survophthal.2005.08.011 .
  4. Sanders DR, Vukich JA . Comparison of implantable contact lens and laser assisted in situ keratomileusis for moderate to high myopia . Cornea . 22 . 4 . 324–31 . May 2003 . 12792475 . 10.1097/00003226-200305000-00009 . 21142105 .
  5. News: Rabin . Roni Caryn . Lasik's Risks Are Coming Into Sharper Focus – Some patients who undergo the eye surgery report a variety of side effects. They may persist for years, studies show. . June 11, 2018 . . June 11, 2018 .
  6. Web site: Nd:YAG Treatment of Epithelial Ingrowth . Dan . Lindfield . Tom . Poole . Cataract and Refractive Surgery Today. 12 September 2013.
  7. Web site: Stodola . Ellen . LASIK worldwide . April 1, 2016 . EyeWorld.org . June 12, 2018 . June 12, 2018 . https://web.archive.org/web/20180612162458/https://www.eyeworld.org/article-lasik-worldwide . dead .
  8. Web site: A Look at LASIK Past, Present and Future. EyeNet Magazine. 12 September 2013. dead. https://web.archive.org/web/20130731030413/http://www.aao.org/publications/eyenet/200906/feature.cfm. 31 July 2013.
  9. Corcoran KJ . Macroeconomic landscape of refractive surgery in the United States . Current Opinion in Ophthalmology . 26 . 4 . 249–54 . July 2015 . 26058020 . 10.1097/ICU.0000000000000159 . 11842503 .
  10. Web site: US FDA/CDRH: LASIK – What are the risks and how can I find the right doctor for me? . U.S. Food and Drug Administration (FDA) . June 9, 2014 . December 23, 2016.
  11. Web site: Am I a Candidate For LASIK Surgery? TLC Laser Eye Centers. Tlcvision.com. 20 December 2018.
  12. Shortt AJ, Allan BD, Evans JR . Laser-assisted in-situ keratomileusis (LASIK) versus photorefractive keratectomy (PRK) for myopia . The Cochrane Database of Systematic Reviews . 1 . 1 . CD005135 . January 2013 . 23440799 . 10.1002/14651858.CD005135.pub3 . There was evidence that LASIK gives a faster visual recovery than PRK and is a less painful technique. Results at one year after surgery were comparable: most analyses favoured LASIK but they were not statistically significant. .
  13. Book: Dimitri T. . Azar . Damien . Gatinel . Refractive surgery. 2007. Mosby Elsevier. Philadelphia. 978-0-323-03599-6. 2nd.
  14. Walsh MJ. Is the future of refractive surgery based on corneal topography or wavefront? "Ocular Surgery News". August 1, 2000, page 26.
  15. Walsh MJ. Wavefront is showing signs of success, but can it do it alone? Ocular Surgery News. September 1, 2000, page 41.
  16. EW Dialogue: the future of wavefront refraction as a diagnostic tool. "EyeWorld". May 2000, pages 64 and 65.
  17. Alpins NA . Wavefront technology: a new advance that fails to answer old questions on corneal vs. refractive astigmatism correction . Journal of Refractive Surgery . 18 . 6 . 737–9 . 2002 . 10.3928/1081-597X-20021101-12 . 12458868 .
  18. Alpins N, Stamatelatos G . Clinical outcomes of laser in situ keratomileusis using combined topography and refractive wavefront treatments for myopic astigmatism . Journal of Cataract and Refractive Surgery . 34 . 8 . 1250–9 . August 2008 . 18655973 . 10.1016/j.jcrs.2008.03.028 . 29819060 .
  19. Alpins N, Stamatelatos G . Customized photoastigmatic refractive keratectomy using combined topographic and refractive data for myopia and astigmatism in eyes with forme fruste and mild keratoconus . Journal of Cataract and Refractive Surgery . 33 . 4 . 591–602 . April 2007 . 17397730 . 10.1016/j.jcrs.2006.12.014 . 14881153 .
  20. American Academy of Ophthalmology. "Refractive Laser Surgery: An In-Depth Look at LASIK and Brief Overview of PRK, Epi-LASIK, and LASEK: A Science Writer's Guide" . Accessed January 29, 2012.
  21. Abbott Medical Optics website. "WaveScan WaveFront System". Accessed August 15, 2012.
  22. Emory Healthcare website. "Wavefront technology" . Accessed August 15, 2012.
  23. Croes K. AllAboutVision website. "Custom LASIK or wavefront LASIK: individualized vision correction". Accessed August 15, 2012.
  24. Web site: Liz . Segre . Cost of LASIK eye surgery and other corrective procedures . Allaboutvision.com . 2012-08-15.
  25. Fares U, Suleman H, Al-Aqaba MA, Otri AM, Said DG, Dua HS . Efficacy, predictability, and safety of wavefront-guided refractive laser treatment: metaanalysis . Journal of Cataract and Refractive Surgery . 37 . 8 . 1465–75 . August 2011 . 21782089 . 10.1016/j.jcrs.2011.02.029 . 26968756 .
  26. Web site: Sue . Campbell . Air Force aims for 'weapons-grade' vision . Af.mil . 2011-12-10 . https://archive.today/20120728134939/http://www.af.mil/news/story.asp?storyID=123009161 . 2012-07-28 . dead .
  27. Web site: Nidek EC-5000 Excimer Laser System – P970053/S011. Food and Drug Administration. 2013-10-13. 2016-05-01.
  28. Web site: Topography-guided LASIK: A paradigm shift in refractive laser treatment. EyeWorld Daily News. Doyle . Stulting . 2014-04-28. 2016-05-01.
  29. Troutman RC, Swinger C . Refractive keratoplasty: keratophakia and keratomileusis . Transactions of the American Ophthalmological Society . 76 . 329–39 . 1978 . 382579 . 1311630 .
  30. Web site: Prize for the Industrial Application of Physics Winner – American Institute of Physics . Aip.org . 2011-12-10 . dead . https://web.archive.org/web/20110928093030/http://www.aip.org/ca/srinivasan.html . 2011-09-28 .
  31. Web site: James Wynne . laserfest.org . 30 December 2021 . 5 February 2023 . https://web.archive.org/web/20230205044704/https://laserfest.org/lasers/pioneers/wynne.cfm . dead .
  32. Cotliar AM, Schubert HD, Mandel ER, Trokel SL . Excimer laser radial keratotomy . Ophthalmology . 92 . 2 . 206–8 . February 1985 . 3982798 . 10.1016/s0161-6420(85)34052-6 .
  33. Web site: VISX - World Leader in Laser Vision Correction Technology used for Conventional LASIK, Wavefront Guided LASIK, PRK, LASEK, and PTK Procedures . 2019-01-25 . https://web.archive.org/web/20151019012412/http://www.visx.com/contact.php . 2015-10-19 . dead .
  34. McDonald MB, Kaufman HE, Frantz JM, Shofner S, Salmeron B, Klyce SD . Excimer laser ablation in a human eye. Case report . Archives of Ophthalmology . 107 . 5 . 641–2 . May 1989 . 2719572 . 10.1001/archopht.1989.01070010659013 .
  35. US4784135 . Far ultraviolet surgical and dental procedures. 1988-11-15 . 1982-12-09 . Samuel E. Blum, Rangaswamy Srinivasan, James J. Wynne.
  36. 1988-6-20 . 1988-1-22 . Gholam A. Peyman . Method for modifying corneal curvature . US4840175.
  37. Web site: FDA-Approved Lasers for PRK and Other Refractive Surgeries . U.S. Food and Drug Administration (FDA) . 2011-12-10.
  38. Web site: List of FDA-Approved Lasers for LASIK . U.S. Food and Drug Administration (FDA) . 2011-12-10.
  39. News: Schoenberg. Nara. May 23, 2016. Lasik surgery falling out of favor with patients. Chicago Tribune.
  40. Stein JD, Childers DM, Nan B, Mian SI. July 2013. Gauging interest of the general public in laser-assisted in situ keratomileusis eye surgery. Cornea. 32. 7. 1015–8. 10.1097/ICO.0b013e318283c85a. 3679260. 23538615.
  41. Web site: March 2006 . Photorefractive (laser) surgery for the correction of refractive errors . National Health Service . pdf.
  42. Web site: 2018-11-03 . LASIK – When is LASIK not for me? . 20 December 2018 . U.S. Food and Drug Administration (FDA).
  43. Saragoussi D, Saragoussi JJ . September 2004 . [Lasik, PRK and quality of vision: a study of prognostic factors and a satisfaction survey] ]. Journal Français d'Ophtalmologie . fr . 27 . 7 . 755–64 . 10.1016/S0181-5512(04)96210-9 . 15499272.
  44. Bailey MD, Mitchell GL, Dhaliwal DK, Boxer Wachler BS, Zadnik K . July 2003 . Patient satisfaction and visual symptoms after laser in situ keratomileusis . Ophthalmology . 110 . 7 . 1371–8 . 10.1016/S0161-6420(03)00455-X . 12867394.
  45. McGhee CN, Craig JP, Sachdev N, Weed KH, Brown AD . Jennifer Craig (academic) . April 2000 . Functional, psychological, and satisfaction outcomes of laser in situ keratomileusis for high myopia . Journal of Cataract and Refractive Surgery . 26 . 4 . 497–509 . 10.1016/S0886-3350(00)00312-6 . 10771222 . 13304987.
  46. Solomon KD, Fernández de Castro LE, Sandoval HP, Biber JM, Groat B, Neff KD, Ying MS, French JW, Donnenfeld ED, Lindstrom RL . April 2009 . LASIK world literature review: quality of life and patient satisfaction . Ophthalmology . 116 . 4 . 691–701 . 10.1016/j.ophtha.2008.12.037 . 19344821.
  47. Sugar A, Hood CT, Mian SI . January 2017 . Patient-Reported Outcomes Following LASIK: Quality of Life in the PROWL Studies . JAMA . 317 . 2 . 204–205 . 10.1001/jama.2016.19323 . 28097345.
  48. News: LASIK Eye Surgery . . 10 September 2013.
  49. Shtein RM . October 2011 . Post-LASIK dry eye . Expert Review of Ophthalmology . 6 . 5 . 575–582 . 10.1586/eop.11.56 . 3235707 . 22174730.
  50. Levinson BA, Rapuano CJ, Cohen EJ, Hammersmith KM, Ayres BD, Laibson PR . January 2008 . Referrals to the Wills Eye Institute Cornea Service after laser in situ keratomileusis: reasons for patient dissatisfaction . Journal of Cataract and Refractive Surgery . 34 . 1 . 32–9 . 10.1016/j.jcrs.2007.08.028 . 18165078 . 11133295.
  51. Jabbur NS, Sakatani K, O'Brien TP . September 2004 . Survey of complications and recommendations for management in dissatisfied patients seeking a consultation after refractive surgery . Journal of Cataract and Refractive Surgery . 30 . 9 . 1867–74 . 10.1016/j.jcrs.2004.01.020 . 15342048 . 25054973.
  52. Rodemich . Karen . 2010 . Former FDA official warns of LASIK risks: the man who OK'd LASIK now warns of an "epidemic" of eye problems . Review of Optometry . 147 . 10 . 4.
  53. News: Cha . Ariana Eunjung . 2016-11-23 . Many LASIK patients may wind up with glare, halos or other visual symptoms, study suggests . . 2018-04-04 . 0190-8286.
  54. Pallikaris IG, Panagopoulou SI . July 2015 . PresbyLASIK approach for the correction of presbyopia . Current Opinion in Ophthalmology . 26 . 4 . 265–72 . 10.1097/icu.0000000000000162 . 26058023 . 35434343.
  55. Pop M, Payette Y . January 2004 . Risk factors for night vision complaints after LASIK for myopia . Ophthalmology . 111 . 1 . 3–10 . 10.1016/j.ophtha.2003.09.022 . 14711706. free .
  56. Padmanabhan P, Basuthkar SS, Joseph R . Jul–Aug 2010 . Ocular aberrations after wavefront optimized LASIK for myopia . Indian Journal of Ophthalmology . 58 . 4 . 307–12 . 10.4103/0301-4738.64139 . 2907032 . 20534921 . free .
  57. http://www.operationauge.com/risks-lasik-lasek-prk.html "Individual Risk Factors of Halos, Loss of Contrast Sensitivity, Glare and Starbursts after LASIK."
  58. Yamane N, Miyata K, Samejima T, Hiraoka T, Kiuchi T, Okamoto F, Hirohara Y, Mihashi T, Oshika T . November 2004 . Ocular higher-order aberrations and contrast sensitivity after conventional laser in situ keratomileusis . Investigative Ophthalmology & Visual Science . 45 . 11 . 3986–90 . 10.1167/iovs.04-0629 . 15505046 . free.
  59. Oshika T, Miyata K, Tokunaga T, Samejima T, Amano S, Tanaka S, Hirohara Y, Mihashi T, Maeda N, Fujikado T . June 2002 . Higher order wavefront aberrations of cornea and magnitude of refractive correction in laser in situ keratomileusis . Ophthalmology . 109 . 6 . 1154–8 . 10.1016/S0161-6420(02)01028-X . 12045059.
  60. Web site: 5 March 2012 . Laser eye surgery . 26 October 2013 . NHS Choices.
  61. Web site: 12 September 2011 . LASIK – What are the risks and how can I find the right doctor for me? . 26 October 2013 . U.S. Food and Drug Administration (FDA) .
  62. Simpson RG, Moshirfar M, Edmonds JN, Christiansen SM, Behunin N . 2012 . Laser in situ keratomileusis in patients with collagen vascular disease: a review of the literature . Clinical Ophthalmology . 6 . 1827–37 . 10.2147/OPTH.S36690 . 3497460 . 23152662 . free .
  63. Web site: 2018-08-08 . LASIK . 2022-07-17 . U.S. Food and Drug Administration (FDA).
  64. Majmudar, PA. "LASIK Complications." Focal Points: Clinical Modules for Ophthalmologists. American Academy of Ophthalmology. September, 2004.
  65. Carrillo C, Chayet AS, Dougherty PJ, Montes M, Magallanes R, Najman J, Fleitman J, Morales A . 2005 . Incidence of complications during flap creation in LASIK using the NIDEK MK-2000 microkeratome in 26,600 cases . Journal of Refractive Surgery . 21 . 5 Suppl . S655-7 . 10.3928/1081-597X-20050902-20 . 16212299.
  66. Web site: Eye Surgery Education Council . dead . https://web.archive.org/web/20110928000153/http://www.lasikinstitute.org/Intraoperative.html . 2011-09-28 . 2011-12-10 . Lasikinstitute.org.
  67. Tham VM, Maloney RK . May 2000 . Microkeratome complications of laser in situ keratomileusis . Ophthalmology . 107 . 5 . 920–4 . 10.1016/S0161-6420(00)00004-X . 10811084.
  68. Vesaluoma M, Pérez-Santonja J, Petroll WM, Linna T, Alió J, Tervo T . February 2000 . Corneal stromal changes induced by myopic LASIK . Investigative Ophthalmology & Visual Science . 41 . 2 . 369–76 . 10670464.
  69. Sun L, Liu G, Ren Y, Li J, Hao J, Liu X, Zhang Y . 2005 . Efficacy and safety of LASIK in 10,052 eyes of 5081 myopic Chinese patients . Journal of Refractive Surgery . 21 . 5 Suppl . S633-5 . 10.3928/1081-597X-20050902-15 . 16212294.
  70. Web site: Ectasia After LASIK . American Academy of Ophthalmology.
  71. Galvis V, Tello A, Ortiz AI, Quintero MP, Parra MM, Blanco NA . April–June 2019 . Traumatic corneal flap avulsion and loss 13 years after LASIK . Saudi Journal of Ophthalmology . 33 . 2 . 172–176 . 10.1016/j.sjopt.2018.08.001 . 6664271 . 31384163 . free.
  72. Ruiz-Moreno JM, Alió JL . 2003 . Incidence of retinal disease following refractive surgery in 9,239 eyes . Journal of Refractive Surgery . 19 . 5 . 534–47 . 10.3928/1081-597X-20030901-08 . 14518742.
  73. Suarez E, Torres F, Vieira JC, Ramirez E, Arevalo JF . October 2002 . Anterior uveitis after laser in situ keratomileusis . Journal of Cataract and Refractive Surgery . 28 . 10 . 1793–8 . 10.1016/S0886-3350(02)01364-0 . 12388030 . 11880947.
  74. Boes DA, Omura AK, Hennessy MJ . December 2001 . Effect of high-altitude exposure on myopic laser in situ keratomileusis . Journal of Cataract and Refractive Surgery . 27 . 12 . 1937–41 . 10.1016/S0886-3350(01)01074-4 . 11738908 . 45468164.
  75. Dimmig JW, Tabin G . 2003 . The ascent of Mount Everest following laser in situ keratomileusis . Journal of Refractive Surgery . 19 . 1 . 48–51 . 10.3928/1081-597X-20030101-10 . 12553606.
  76. Hammer T, Heynemann M, Naumann I, Duncker GI . March 2006 . [Correction and induction of high-order aberrations after standard and wavefront-guided LASIK and their influence on the postoperative contrast sensitivity] . Klinische Monatsblätter für Augenheilkunde . de . 223 . 3 . 217–24 . 10.1055/s-2005-858864 . 16552654. 71611964 .
  77. Alió JL, Montés-Mico R . February 2006 . Wavefront-guided versus standard LASIK enhancement for residual refractive errors . Ophthalmology . 113 . 2 . 191–7 . 10.1016/j.ophtha.2005.10.004 . 16378639.
  78. Caster AI, Hoff JL, Ruiz R . 2005 . Conventional vs wavefront-guided LASIK using the LADARVision4000 excimer laser . Journal of Refractive Surgery . 21 . 6 . S786-91 . 10.3928/1081-597X-20051101-28 . 16329381.
  79. Web site: 2018-11-03 . LASIK – What are the risks and how can I find the right doctor for me? . U.S. Food and Drug Administration (FDA) . 20 December 2018.
  80. Web site: LASIK laser eye surgery . dead . https://web.archive.org/web/20160515073430/http://www.webmd.boots.com/eye-health/guide/lasik-laser-eye-surgery . 2016-05-15 . 2016-05-06 . Webmd.boots.com .
  81. News: St. Philip . Elizabeth . Favaro . Avis . April 7, 2019 . Families deal with repercussions after rare but severe complications from laser eye surgery . CTV . 26 November 2019.
  82. Web site: LASIK Quality of Life Collaboration Project . 28 November 2014 . U.S. Food and Drug Administration.
  83. Web site: 2019-04-26 . Latest on FDA's LASIK Program . U.S. Food and Drug Administration.
  84. LASIK Quality of Life Collaboration Project: Study Results Presented at the Refractive Surgery Subspecialty Day of the American Academy of Ophthalmology (AAO) on October 17, 2014 (PDF – 1.8MB)
  85. Web site: What are the risks and how can I find the right doctor for me? . 2015-12-03 . U.S. Food and Drug Administration (FDA) .
  86. Web site: LASIK for Myopia and Astigmatism: Safety and Efficacy – EyeWiki . 2019-08-06 . eyewiki.aao.org.
  87. Web site: 2018-11-03 . When is LASIK not for me? . U.S. Food and Drug Administration (FDA) .
  88. Web site: Time to Revisit Surface Ablation?. Sean. McKinney. www.reviewofophthalmology.com.
  89. Avedro Receives the European Union's CE Mark for its Vedera Ophthalmic Device. April 20, 2010. Avedro.com. 20 December 2018. 4 November 2013. https://web.archive.org/web/20131104093214/http://www.avedro.com/PressReleases/Avedro_CEMark_20April2010.pdf. dead.
  90. Web site: CRSTodayEurope.com > May 2010 > Industry interview: Aiming to change the face of refractive surgery—again . Bmctoday.net . 2010-04-16 . 2011-12-10.
  91. Web site: IntraCOR for presbyopia. 2010pv.com. 20 December 2018. https://web.archive.org/web/20110902212944/http://www.2010pv.com/dasat/images/3/100373-luis-ruiz-white-paper-0908-final.PDF. 2011-09-02. dead.
  92. Web site: IntraCOR for myopia. 2010pv.com. 20 December 2018. https://web.archive.org/web/20110902213023/http://www.2010pv.com/dasat/images/4/100544-1st-tpv-alliance-bali-may-2009.pdf. 2011-09-02. dead.
  93. Chen S, Feng Y, Stojanovic A, Jankov MR, Wang Q . IntraLase femtosecond laser vs mechanical microkeratomes in LASIK for myopia: a systematic review and meta-analysis . Journal of Refractive Surgery . 28 . 1 . 15–24 . January 2012 . 22233436 . 10.3928/1081597x-20111228-02 . 1 November 2015 . 7 January 2022 . https://web.archive.org/web/20220107065657/https://www.laservalais.ch/wp-content/uploads/Journal-of-Refractive-Surgery-Janvier-2012.pdf . dead .
  94. Shortt AJ, Allan BD, Evans JR . Laser-assisted in-situ keratomileusis (LASIK) versus photorefractive keratectomy (PRK) for myopia . The Cochrane Database of Systematic Reviews . 1 . 1 . CD005135 . January 2013 . 23440799 . 10.1002/14651858.CD005135.pub3 .
  95. Kuryan J, Cheema A, Chuck RS . Laser-assisted subepithelial keratectomy (LASEK) versus laser-assisted in-situ keratomileusis (LASIK) for correcting myopia . The Cochrane Database of Systematic Reviews . 2017 . 2 . CD011080 . February 2017 . 28197998 . 5408355 . 10.1002/14651858.CD011080.pub2 .

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