| State: | NV |
| Type: | BL |
| Route: | 80 |
| Alternate Name: | Winnemucca Boulevard |
| Map Custom: | yes |
| Length Mi: | 4.4 |
| Length Round: | 1 |
| Established: | 1982 |
| Direction A: | West |
| Terminus A: | in Winnemucca |
| Junction: | in Winnemucca |
| Direction B: | East |
| Terminus B: | northeast of Winnemucca |
| Spur Of: | 80 |
| Spur Type: | I |
| Counties: | Humboldt |
Interstate 80 Business (I-80 Bus) is an Interstate business route in Humboldt County, Nevada. Serving the city of Winnemucca along Winnemucca Boulevard, I-80 Bus is also cosigned along portions of three other state highways through the city:
I-80 Bus starts south of the incorporated city at exit 176 on I-80/US 95. The highway heads northeast concurrent with US 95 and parallel to US 80 and a railway through Winnemucca. Traveling further north, the route gets to an intersection with Melarkey Street, where US 95 leaves I-80 Bus and runs north under I-80. At this intersection, the business loop now runs concurrently with SR 289 until it branches off to the east, and SR 289 continues to the northeast under I-80. Over the final stretch from this intersection to its eastern terminus at exit 180 on I-80, I-80 Bus runs concurrently with SR 794, also named East Winnemucca Boulevard.
The I-80 Bus designation was first approved by the American Association of State Highway and Transportation Officials (AASHTO) at its spring meeting on June 28, 1982.