Interolog Explained

An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.^{[1] [2]}

Example

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

• A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
• B is a homolog of B'.
• A and B interact.
• A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

See also

• Homology (biology)
• Systems biology
• Bioinformatics

References

• Yu . H. . Luscombe . N. M. . Lu . H. X. . Zhu . X. . Xia . Y. . Han . J. D. . Bertin . N. . Chung . S. . Vidal . M. . Gerstein . M. . Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs . 10.1101/gr.1774904 . Genome Research . 14 . 6 . 1107–1118 . 2004 . 15173116 . 419789 .
• Kemmer . D. . Huang . Y. . Shah . S. P. . Lim . J. . Brumm . J. . Yuen . M. M. . Ling . J. . Xu . T. . Wasserman . W. W. . Ouellette . B. F. . Ulysses - an application for the projection of molecular interactions across species . Genome Biology . 6 . 12 . R106 . 10.1186/gb-2005-6-12-r106 . 2005 . 16356269 . 1414088 . free .
• Wiles . A. M. . Doderer . M. . Ruan . J. . Gu . T. T. . Ravi . D. . Blackman . B. . Bishop . A. J. . Building and analyzing protein interactome networks by cross-species comparisons . 10.1186/1752-0509-4-36 . BMC Systems Biology . 4 . 36 . 2010 . 20353594 . 2859380 . free .

External links

• Interactome.org : Interactome portal site.
• Interactomics.org : Interactomics portal site.
• http://www.interologfinder.org: Cross-species interaction prediction site.

Notes and References

1. Walhout . A. J. . Sordella . R. . Lu . X. . Hartley . J. L. . Temple . G. F. . Brasch . M. A. . Thierry-Mieg . N. . Vidal . M. . 10.1126/science.287.5450.116 . Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development . Science . 287 . 5450 . 116–122 . 2000 . 10615043. 2000Sci...287..116W .
2. 10.1101/gr.1774904. 15173116. 419789. Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs. Genome Research. 14. 6. 1107–1118. 2004. Yu. H.. Luscombe. N. M.. Lu. H. X.. Zhu. X.. Xia. Y.. Han. J. D.. Bertin. N.. Chung. S.. Vidal. M.. Gerstein. M..