Alpha-taxilin explained

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.^{[1] [2] [3]}

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.^[4] This molecule was also recently designated taxilin.^[5] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.^[6] The il14 locus is near the gene for LCK on chromosome 1 in humans.

Further reading

• Ambrus JL, Pippin J, Joseph A . Identification of a cDNA for a human high-molecular-weight B-cell growth factor . Proc. Natl. Acad. Sci. U.S.A. . 90 . 13 . 6330–4 . 1993 . 8327514 . 10.1073/pnas.90.13.6330 . 46922 . 1993PNAS...90.6330A . etal. free .
• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Ambrus JL, Pippin J, Joseph A . Identification of a cDNA for a human high molecular-weight B-cell growth factor . Proc. Natl. Acad. Sci. U.S.A. . 93 . 15 . 8154 . 1996 . 8755619 . . 38894 . etal.
• Yu W, Andersson B, Worley KC . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Nogami S, Satoh S, Nakano M . Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells . Genes Cells . 8 . 1 . 17–28 . 2003 . 12558796 . 10.1046/j.1365-2443.2003.00612.x . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Shen L, Zhang C, Wang T . Development of autoimmunity in IL-14alpha-transgenic mice . J. Immunol. . 177 . 8 . 5676–86 . 2007 . 10.4049/jimmunol.177.8.5676 . 17015757 . 86324456 . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H . Identification and characterization of taxilin isoforms . Biochem. Biophys. Res. Commun. . 319 . 3 . 936–43 . Jun 2004 . 15184072 . 10.1016/j.bbrc.2004.05.073 .
2. Nogami S, Satoh S, Nakano M, Terano A, Shirataki H . Interaction of taxilin with syntaxin which does not form the SNARE complex . Biochem. Biophys. Res. Commun. . 311 . 4 . 797–802 . Nov 2003 . 14623251 . 10.1016/j.bbrc.2003.10.069 .
3. Web site: Entrez Gene: TXLNA taxilin alpha.
4. Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ . Identification of a cDNA for a human high-molecular-weight B-cell growth factor . Proc. Natl. Acad. Sci. U.S.A. . 90 . 13 . 6330–4 . July 1993 . 8327514 . 46922 . 10.1073/pnas.90.13.6330. 1993PNAS...90.6330A . free .
5. Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H . Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells . Genes Cells . 8 . 1 . 17–28 . January 2003 . 12558796 . 10.1046/j.1365-2443.2003.00612.x. free .
6. Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL . Development of autoimmunity in IL-14alpha-transgenic mice . J. Immunol. . 177 . 8 . 5676–86 . October 2006 . 10.4049/jimmunol.177.8.5676 . 17015757 . 86324456 . free .