Interleukin-27 receptor explained
| interleukin 27 receptor, alpha |
| Hgncid: | 17290 |
| Symbol: | IL27RA |
| Altsymbols: | WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R |
| Entrezgene: | 9466 |
| Omim: | 605350 |
| Refseq: | NM_004843 |
| Uniprot: | Q6UWB1 |
| Chromosome: | 19 |
| Arm: | p |
| Band: | 13.11 |
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1] [2] and glycoprotein 130.[3]
IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4]
Notes and References
- Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF . Cloning and characterization of a novel class I cytokine receptor . Biochem. Biophys. Res. Commun. . 246 . 1 . 82–90 . 1998 . 9600072 . 10.1006/bbrc.1998.8576 .
- Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ . Development of Th1-type immune responses requires the type I cytokine receptor TCCR . Nature . 407 . 6806 . 916–20 . 2000 . 11057672 . 10.1038/35038103 . 2000Natur.407..916C . 205009928 .
- Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA . WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 . Journal of Immunology . 172 . 4 . 2225–31 . February 2004 . 14764690 . 10.4049/jimmunol.172.4.2225. free .
- Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H . Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment . J. Immunol. . 170 . 10 . 4886–90 . May 2003 . 12734330 . 10.4049/jimmunol.170.10.4886. free .
