Interleukin-12 receptor explained

interleukin 12 receptor, beta 1
Hgncid:	5971
Symbol:	IL12RB1
Altsymbols:	IL12RB, CD212
Entrezgene:	3594
Omim:	601604
Refseq:	NM_005535
Uniprot:	P42701
Chromosome:	19
Arm:	p
Band:	13.1

beta 2 subunit, interleukin 12 receptor, beta 2
Hgncid:	5972
Symbol:	IL12RB2
Entrezgene:	3595
Omim:	601642
Refseq:	NM_001559
Uniprot:	Q99665
Chromosome:	1
Arm:	p
Band:	31.3-31.2

Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1^[1] and beta 2 subunits.^[2]

Notes and References

1. Chua AO, Chizzonite R, Desai BB, Truitt TP, Nunes P, Minetti LJ, Warrier RR, Presky DH, Levine JF, Gately MK . Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130 . J. Immunol. . 153 . 1 . 128–36 . 1994 . 10.4049/jimmunol.153.1.128 . 7911493 . 9211163 .
2. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U . A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits . Proc. Natl. Acad. Sci. U.S.A. . 93 . 24 . 14002–14007 . 1996 . 8943050 . 10.1073/pnas.93.24.14002 . 19484 . 1996PNAS...9314002P . free .