| Country: | MYS |
| Route: | 500 |
| Interior North South Highway | |
| Length Km: | 186 |
| Length Round: | 1 |
| Direction A: | Northwest |
| Terminus A: | Ranau (continues as Pan Borneo Highway) |
| Junction: | Federal Route 22 Malaysia Federal Route 500 Jalan Penampang Jalan Ranau-Tambunan Kimanis-Keningau Highway Jalan Tawau-Keningau |
| Direction B: | Southeast |
| Terminus B: | Kemabung (continues to Tomani) |
| Destinations: | Tambunan, Keningau, Sook(continues to Tawau), Tenom |
Interior North South Highway is a federal highway in Sabah, Malaysia, connecting Ranau to Kemabung. It serves as the main highway to replace Malaysia Federal Route 500 from Kota Kinabalu to towns and villages in the Interior Division of Sabah.
The length of the entire highway is expected to be about 186km (116miles) for the Malaysian section.
| Km | Exit | Interchange | To | Remarks | |
|---|---|---|---|---|---|
| Ranau | Junctions | ||||
| -- m above sea level | Tambunan bound, Engage lower gear | ||||
| Tambunan Tambunan Roundabout | Jalan Ranau-Tambunan Ranau Kundasang Sandakan | Roundabout | |||
| Tambunan | Tambunan town centre | Roundabout | |||
| -- m above sea level | Keningau bound, Engage lower gear | ||||
| Apin-Apin | Junctions | ||||
| Keningau Town Hospital | Keningau Town Hospital | Roundabout | |||
| Keningau | Kimanis-Keningau Highway Northwest Crocker Range National Park Kimanis | Roundabout | |||
| Keningau Jalan Keningau-Sook | Jalan Keningau-Sook Sook Nabawan Kalabakan Tawau | Signalised T-junction | |||
| Jalan Patikang Ulu | Jalan Patikang Ulu Kimanis | T-junction | |||
| Melalap | |||||
| Tenom | Jalan Tenom-Ponontomon Ponontomon Sabah Agriculture Park | Roundabout | |||
| Southwest Jalan Tenom-Sipitang Sipitang Sindumin Lawas | |||||
| -- m above sea level | Tenom bound, Engage lower gear | ||||
| SMK Kemabong | SMK Kemabong | Roundabout | |||
| Kemabung | Kemabung District | Roundabout |