Intergenic lcrF RNA thermometer explained

LcrF intergenic thermometer
Rfam:	RF02704
Tax Domain:	Bacteria
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RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.^{[1] [2]}

Notes and References

1. Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P . Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence . PLOS Pathogens . 8 . 2 . e1002518 . February 2012 . 22359501 . 3280987 . 10.1371/journal.ppat.1002518 . free .
2. Schwiesow L, Lam H, Dersch P, Auerbuch V . Yersinia Type III Secretion System Master Regulator LcrF . Journal of Bacteriology . 198 . 4 . 604–614 . December 2015 . 26644429 . 4751813 . 10.1128/JB.00686-15 .