Interferon gamma receptor (IFNGR1) family explained

Symbol:	IFNGR1
Interferon gamma receptor (IFNGR1)
Pfam:	PF07140
Pfam Clan:	CL0159
Interpro:	IPR008355
Scop:	1fg9
Membranome Family:	1318

In molecular biology, the interferon gamma receptor (IFNGR1) family is a family of proteins which includes several eukaryotic and viral interferon gamma receptor proteins.

Members of this family include:

• The human interferon gamma receptor 1, which is a member of the hematopoietic cytokine receptor superfamily. It is expressed in a membrane-bound form in many cell types, and is over-expressed in tumour cells. It comprises an extracellular portion of 229 amino acid residues, a single transmembrane region, and a cytoplasmic domain of 221 amino acid residues. As with other members of its superfamily, the cytokine-binding sites are formed by a small set of closely spaced surface loops that extend from a beta-sheet core, much like antigen-binding sites on antibodies.^[1]
• The vaccinia virus interferon (IFN)-gamma receptor (IFN-gammaR), which is a 43 kDa soluble glycoprotein that is secreted from infected cells early during infection. IFN-gammaR from vaccinia virus, cowpox virus and camelpox virus exist naturally as homodimers, whereas the cellular IFN-gammaR dimerises only upon binding the homodimeric IFN-gamma. The existence of the virus protein as a dimer in the absence of ligand may provide an advantage to the virus in efficient binding and inhibition of IFN-gamma in solution.^[2]

Notes and References

1. Sogabe S, Stuart F, Henke C, Bridges A, Williams G, Birch A, Winkler FK, Robinson JA . Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex . J. Mol. Biol. . 273 . 4 . 882–97 . November 1997 . 9367779 . 10.1006/jmbi.1997.1336 .
2. . The vaccinia virus soluble interferon-gamma receptor is a homodimer . J. Gen. Virol. . 83 . Pt 3 . 545–9 . March 2002 . 11842249 . 10.1099/0022-1317-83-3-545. free .