| Interferon gamma 5' UTR regulatory element | |
| Symbol: | IFN_gamma |
| Rfam: | RF00259 |
| Rna Type: | Cis-reg |
| Tax Domain: | Eukaryota |
Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.[1]