Integrin alpha D explained

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.^{[1] [2] [3]}

Further reading

• Van der Vieren M, Le Trong H, Wood CL, etal . A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3. . Immunity . 3 . 6 . 683–90 . 1996 . 8777714 . 10.1016/1074-7613(95)90058-6. free .
• Grayson MH, Van der Vieren M, Sterbinsky SA, etal . alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). . J. Exp. Med. . 188 . 11 . 2187–91 . 1999 . 9841932 . 10.1084/jem.188.11.2187 . 2212388 .
• Van der Vieren M, Crowe DT, Hoekstra D, etal . The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. . J. Immunol. . 163 . 4 . 1984–90 . 1999 . 10.4049/jimmunol.163.4.1984 . 10438935 .
• Noti JD, Johnson AK, Dillon JD . Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3. . J. Biol. Chem. . 275 . 12 . 8959–69 . 2000 . 10722744 . 10.1074/jbc.275.12.8959 . free .
• Noti JD . Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins. . Int. J. Mol. Med. . 10 . 6 . 721–7 . 2003 . 12429998 . 10.3892/ijmm.10.6.721.
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Noti JD, Johnson AK, Dillon JD . The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells. . J. Biol. Chem. . 280 . 5 . 3449–57 . 2005 . 15561714 . 10.1074/jbc.M412627200 . free .

External links

• ITGAD Info with links in the Cell Migration Gateway

Notes and References

1. Wong DA, Davis EM, LeBeau M, Springer TA . Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit . Gene . 171 . 2 . 291–4 . Aug 1996 . 8666289 . 10.1016/0378-1119(95)00869-1 .
2. Shelley CS, Da Silva N, Georgakis A, Chomienne C, Arnaout MA . Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb . Genomics . 49 . 2 . 334–6 . Aug 1998 . 9598326 . 10.1006/geno.1998.5232 .
3. Web site: Entrez Gene: ITGAD integrin, alpha D.