Integrin alpha 3 explained

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.^{[1] [2]} ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[3]

Interactions

CD49c has been shown to interact with:

• CD9^{[4] [5]}
• FHL2,^[6]
• LGALS8,^[7] and
• TSPAN4.^[8]

Further reading

• Bosman FT . Integrins: cell adhesives and modulators of cell function. . Histochem. J. . 25 . 7 . 469–77 . 1993 . 8407358 . 10.1007/BF00159282 . 19661102 .
• Fornaro M, Languino LR . Alternatively spliced variants: a new view of the integrin cytoplasmic domain. . Matrix Biol. . 16 . 4 . 185–93 . 1998 . 9402008 . 10.1016/S0945-053X(97)90007-X . free .

External links

• • ITGA3 Info with links in the Cell Migration Gateway

Notes and References

1. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME . Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen . J Cell Biol . 115 . 1 . 257–66 . October 1991 . 1655803 . 2289928 . 10.1083/jcb.115.1.257 .
2. Jones SD, van der Flier A, Sonnenberg A . Genomic organization of the human alpha 3 integrin subunit gene . Biochem Biophys Res Commun . 248 . 3 . 896–8 . September 1998 . 9704023 . 10.1006/bbrc.1998.9071 .
3. Web site: Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor).
4. Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S . CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1) . Mol. Hum. Reprod. . 6 . 3 . 252–7 . March 2000 . 10694273 . 10.1093/molehr/6.3.252. free .
5. Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S . CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5 . Mol. Hum. Reprod. . 5 . 2 . 162–7 . February 1999 . 10065872 . 10.1093/molehr/5.2.162. free .
6. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M . The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes . J. Biol. Chem. . 275 . 43 . 33669–78 . October 2000 . 10906324 . 10.1074/jbc.M002519200 . free .
7. Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y . Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis . J. Cell Sci. . 113 . 13. 2385–97 . July 2000 . 10.1242/jcs.113.13.2385 . 10852818 .
8. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME . NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins . J. Biol. Chem. . 272 . 46 . 29181–9 . November 1997 . 9360996 . 10.1074/jbc.272.46.29181. free .