Integrin alpha 11 explained

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.^[1]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.^[2]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.^[3] Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal fibrosis, and lung fibrosis tissues.^[4] ITGA11 has also been found to be upregulated in the tumor stroma of pancreatic ductal adenocarcinoma. ^[5] Knocking down of ITGA11 in human pancreatic stellate cells led to the inhibition of their differentiation into myofibroblasts and paracrine effect on tumor cells.

Further reading

• Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS . 6 . Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells . Proceedings of the National Academy of Sciences of the United States of America . 104 . 28 . 11754–11759 . July 2007 . 17600088 . 1913903 . 10.1073/pnas.0703040104 . free . 2007PNAS..10411754Z .
• Leomil Coelho LF, Mota BE, Sales PC, Marques JT, de Oliveira JG, Bonjardim CA, Peregrino Ferreira PC, Kroon EG . 6 . Integrin alpha 11 is a novel type I interferon stimulated gene . Cytokine . 33 . 6 . 352–361 . March 2006 . 16697656 . 10.1016/j.cyto.2006.03.007 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . 6 . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–716 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S . 6 . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nature Genetics . 36 . 1 . 40–45 . January 2004 . 14702039 . 10.1038/ng1285 . free .
• Zhang WM, Kapyla J, Puranen JS, Knight CG, Tiger CF, Pentikainen OT, Johnson MS, Farndale RW, Heino J, Gullberg D . 6 . alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens . The Journal of Biological Chemistry . 278 . 9 . 7270–7277 . February 2003 . 12496264 . 10.1074/jbc.M210313200 . free .
• Zhang WM, Popova SN, Bergman C, Velling T, Gullberg MK, Gullberg D . Analysis of the human integrin alpha11 gene (ITGA11) and its promoter . Matrix Biology . 21 . 6 . 513–523 . October 2002 . 12392762 . 10.1016/S0945-053X(02)00054-9 .
• Tiger CF, Fougerousse F, Grundström G, Velling T, Gullberg D . alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells . Developmental Biology . 237 . 1 . 116–129 . September 2001 . 11518510 . 10.1006/dbio.2001.0363 . 52235811 . free .
• Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D . cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues . The Journal of Biological Chemistry . 274 . 36 . 25735–25742 . September 1999 . 10464311 . 10.1074/jbc.274.36.25735 . free .

External links

• Web site: ITGA11 Orthologs . Cell Migration Gateway . Cell Migration Consortium . 2021-04-30 . 2013-04-14 . https://archive.today/20130414122456/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=22801 . dead .

Notes and References

1. Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW . 6 . Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11) . Genomics . 60 . 2 . 179–187 . September 1999 . 10486209 . 10.1006/geno.1999.5909 .
2. Web site: Entrez Gene: ITGA11 integrin, alpha 11.
3. Byström B, Carracedo S, Behndig A, Gullberg D, Pedrosa-Domellöf F . Alpha11 integrin in the human cornea: importance in development and disease . Investigative Ophthalmology & Visual Science . 50 . 11 . 5044–5053 . November 2009 . 19516006 . 10.1167/iovs.08-3261 . free .
4. Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman SL, Hoshida Y, Prakash J . 6 . Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases . Experimental & Molecular Medicine . 49 . 11 . e396 . November 2017 . 29147013 . 5704196 . 10.1038/emm.2017.213 .
5. Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J . Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer . FASEB Journal . 33 . 5 . 6609–6621 . May 2019 . 30808244 . 10.1096/fj.201802336R . 73482848 . free .