Integrin alpha 10 explained

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^{[1] [2] [3]}

Function

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[1]

Related gene problems

• TAR syndrome^[4]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

Further reading

• Camper L, Hellman U, Lundgren-Akerlund E . Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes . J. Biol. Chem. . 273 . 32 . 20383–9 . 1998 . 9685391 . 10.1074/jbc.273.32.20383. free .
• Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E . Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants . Matrix Biol. . 20 . 8 . 565–76 . 2001 . 11731273 . 10.1016/S0945-053X(01)00164-0.
• Brakebusch C, Hirsch E, Potocnik A, Fässler R . Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules . J. Cell Sci. . 110 . 23. 2895–904 . 1997 . 10.1242/jcs.110.23.2895 . 9359872 .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697.
• Lehnert K, Ni J, Leung E, etal . The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization . Cytogenet. Cell Genet. . 87 . 3–4 . 238–44 . 1999 . 10702680 . 10.1159/000015434. 85257405 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Svoboda KK . Chondrocyte-matrix attachment complexes mediate survival and differentiation . Microsc. Res. Tech. . 43 . 2 . 111–22 . 1998 . 9822998 . 10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O . 15611353 . free .
• Bengtsson T, Aszodi A, Nicolae C, etal . Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes . J. Cell Sci. . 118 . Pt 5 . 929–36 . 2005 . 15713743 . 10.1242/jcs.01678 . free .
• Wenke AK, Rothhammer T, Moser M, Bosserhoff AK . Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1 . Biochem. Biophys. Res. Commun. . 345 . 1 . 495–501 . 2006 . 16684505 . 10.1016/j.bbrc.2006.04.123 .

External links

• ITGA10 Info with links in the Cell Migration Gateway

Notes and References

1. Web site: Entrez Gene: ITGA10 integrin, alpha 10 .
2. Camper L, Hellman U, Lundgren-Akerlund E . Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes . J. Biol. Chem. . 273 . 32 . 20383–9 . August 1998 . 9685391 . 10.1074/jbc.273.32.20383. free .
3. Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW . The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization . Cytogenet. Cell Genet. . 87 . 3–4 . 238–44 . 1999 . 10702680 . 10.1159/000015434. 85257405 .
4. Klopocki E, Schulze H, Strauss G, etal . Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome . Am. J. Hum. Genet. . 80 . 2 . 232–40 . February 2007 . 17236129 . 1785342 . 10.1086/510919 .