Integrin alpha-1 explained

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.^[1]

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.^[2] It has been shown to affect the motility of T cells.^[3]

Further reading

• Virtanen I, Korhonen M, Kariniemi AL . Integrins in human cells and tumors. . Cell Differ. Dev. . 32 . 3 . 215–27 . 1991 . 2099238 . 10.1016/0922-3371(90)90034-T . etal.
• Plenz GA, Deng MC, Robenek H, Völker W . Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. . Atherosclerosis . 166 . 1 . 1–11 . 2003 . 12482545 . 10.1016/S0021-9150(01)00766-3 .
• Clover J, Dodds RA, Gowen M . Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. . J. Cell Sci. . 103 . 1. 267–71 . 1992 . 10.1242/jcs.103.1.267 . 1429908 .
• Bodary SC, McLean JW . The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. . J. Biol. Chem. . 265 . 11 . 5938–41 . 1990 . 10.1016/S0021-9258(19)39269-5 . 1690718 . free .
• Sonnenberg A, Linders CJ, Modderman PW . Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. . J. Cell Biol. . 110 . 6 . 2145–55 . 1990 . 1693624 . 10.1083/jcb.110.6.2145 . 2116116 . etal.
• Belkin VM, Belkin AM, Dol'nikova AE . [Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] . Biokhimiia . 56 . 12 . 2198–206 . 1992 . 1807406 . etal.
• Bank I, Roth D, Book M . Expression and functions of very late antigen 1 in inflammatory joint diseases. . J. Clin. Immunol. . 11 . 1 . 29–38 . 1991 . 1827128 . 10.1007/BF00918792 . 6198792 . etal.
• Tabibzadeh S . Evidence of T-cell activation and potential cytokine action in human endometrium. . J. Clin. Endocrinol. Metab. . 71 . 3 . 645–9 . 1990 . 2144294 . 10.1210/jcem-71-3-645 .
• Tawil NJ, Houde M, Blacher R . Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. . Biochemistry . 29 . 27 . 6540–4 . 1990 . 2169872 . 10.1021/bi00479a028 . 2710132 . etal.
• Belkin VM, Belkin AM, Koteliansky VE . Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. . J. Cell Biol. . 111 . 5 Pt 1 . 2159–70 . 1990 . 2229189 . 10.1083/jcb.111.5.2159 . 2116325 .
• MacDonald TT, Horton MA, Choy MY, Richman PI . Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. . J. Clin. Pathol. . 43 . 4 . 313–5 . 1990 . 2341567 . 10.1136/jcp.43.4.313 . 502365 .
• Takada Y, Strominger JL, Hemler ME . The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 10 . 3239–43 . 1987 . 3033641 . 10.1073/pnas.84.10.3239 . 304844 . 1987PNAS...84.3239T . free .
• Hemler ME, Huang C, Schwarz L . The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. . J. Biol. Chem. . 262 . 7 . 3300–9 . 1987 . 10.1016/S0021-9258(18)61504-2 . 3546305 . free .
• Kono Y, Yang S, Letarte M, Roberts EA . Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system. . Exp. Cell Res. . 221 . 2 . 478–85 . 1996 . 7493648 . 10.1006/excr.1995.1399 .
• Eglinton BA, Roberton DM, Cummins AG . Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. . Immunol. Cell Biol. . 72 . 4 . 306–13 . 1995 . 7806264 . 10.1038/icb.1994.46 . 25016970 .
• Salter DM, Godolphin JL, Gourlay MS . Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees. . J. Histochem. Cytochem. . 43 . 4 . 447–57 . 1995 . 7897185 . 10.1177/43.4.7897185. free .
• Pfaff M, Aumailley M, Specks U . Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI. . Exp. Cell Res. . 206 . 1 . 167–76 . 1993 . 8387021 . 10.1006/excr.1993.1134 . etal.
• Briesewitz R, Epstein MR, Marcantonio EE . Expression of native and truncated forms of the human integrin alpha 1 subunit. . J. Biol. Chem. . 268 . 4 . 2989–96 . 1993 . 10.1016/S0021-9258(18)53871-0 . 8428973 . free .
• Langholz O, Röckel D, Mauch C . Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. . J. Cell Biol. . 131 . 6 Pt 2 . 1903–15 . 1996 . 8557756 . 10.1083/jcb.131.6.1903 . 2120685 . etal.
• Gardner H, Kreidberg J, Koteliansky V, Jaenisch R . Deletion of Integrin Alpha1 by Homologous Recombination Permits Normal Murine Development But Gives Rise to a Specific Deficit in Cell Adhesion. . Dev. Biol. . 175 . 2 . 301–313 . 1996 . 8626034 . 10.1006/dbio.1996.0116. free .

External links

• • ITGA1 Info with links in the Cell Migration Gateway
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1

Notes and References

1. Book: Gardner . Humphrey . Integrin α1β1 . I Domain Integrins . Advances in Experimental Medicine and Biology . 2014 . 819 . 21–39 . 10.1007/978-94-017-9153-3_2. 25023165 . 978-94-017-9152-6 .
2. Reilly . Emma C. . Sportiello . Mike . Emo . Kris Lambert . Amitrano . Andrea M. . Jha . Rakshanda . Kumar . Ashwin B. R. . Laniewski . Nathan G. . Yang . Hongmei . Kim . Minsoo . Topham . David J. . CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection . Frontiers in Immunology . 9 September 2021 . 12 . 728669 . 10.3389/fimmu.2021.728669 . 34566986 . 8462271 . free .
3. Reilly . EC . Lambert Emo . K . Buckley . PM . Reilly . NS . Smith . I . Chaves . FA . Yang . H . Oakes . PW . Topham . DJ . T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. . Proceedings of the National Academy of Sciences of the United States of America . 2 June 2020 . 117 . 22 . 12306–12314 . 10.1073/pnas.1915681117 . 32439709 . 7275699 . free .