Insulin-like growth factor II IRES explained
| Insulin-like growth factor II IRES |
| Symbol: | IRES_IGF2 |
| Rfam: | RF00483 |
| Rna Type: | Cis-reg
- IRES
|
| Tax Domain: | Eukaryota |
The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1] Ribosomal scanning on human insulin-like growth factor II (IGF-II) is hard to comprehend due to one open reading frame and the ability for the hormone to fold into a stable structure.[2]
External links
Notes and References
- Pedersen SK, Christiansen J, Hansen T, Larsen MR, Nielsen FC . Human insulin-like growth factor II leader 2 mediates internal initiation of translation . The Biochemical Journal . 363 . Pt 1 . 37–44 . April 2002 . 11903044 . 1222448 . 10.1042/0264-6021:3630037 .
- van der Velden AW, van Nierop K, Voorma HO, Thomas AA . Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1 . The International Journal of Biochemistry & Cell Biology . 34 . 3 . 286–297 . March 2002 . 11849996 . 10.1016/S1357-2725(01)00116-9 .
