IGFBP1 explained

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.^{[1] [2]}

Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

Further reading

• Rajaram S, Baylink DJ, Mohan S . Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. . Endocr. Rev. . 18 . 6 . 801–31 . 1998 . 10.1210/edrv.18.6.0321 . 9408744 . free .
• Ferry RJ, Cerri RW, Cohen P . Insulin-like growth factor binding proteins: new proteins, new functions. . Horm. Res. . 51 . 2 . 53–67 . 1999 . 10352394 . 10.1159/000023315 . 2710234 .
• Firth SM, Baxter RC . Cellular actions of the insulin-like growth factor binding proteins. . Endocr. Rev. . 23 . 6 . 824–54 . 2003 . 12466191 . 10.1210/er.2001-0033 . free .
• Wood AW, Duan C, Bern HA . Insulin-like growth factor signaling in fish. . Int. Rev. Cytol. . International Review of Cytology . 243 . 215–85 . 2005 . 15797461 . 10.1016/S0074-7696(05)43004-1 . 9780123646477 .
• Ehrenborg E, Larsson C, Stern I, etal . Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. . Genomics . 12 . 3 . 497–502 . 1992 . 1373120 . 10.1016/0888-7543(92)90440-4 .
• Ekstrand J, Ehrenborg E, Stern I, etal . The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12. . Genomics . 6 . 3 . 413–8 . 1990 . 1691735 . 10.1016/0888-7543(90)90470-F .
• Suwanichkul A, Cubbage ML, Powell DR . The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1. . J. Biol. Chem. . 265 . 34 . 21185–93 . 1991 . 10.1016/S0021-9258(17)45344-0 . 1701175 . free .
• Brinkman A, Kortleve DJ, Schuller AG, etal . Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. . FEBS Lett. . 291 . 2 . 264–8 . 1991 . 1718783 . 10.1016/0014-5793(91)81298-M . 42755060 .
• Brewer MT, Stetler GL, Squires CH, etal . Cloning, characterization, and expression of a human insulin-like growth factor binding protein. . Biochem. Biophys. Res. Commun. . 152 . 3 . 1289–97 . 1988 . 2454104 . 10.1016/S0006-291X(88)80425-X .
• Julkunen M, Koistinen R, Aalto-Setälä K, etal . Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. . FEBS Lett. . 236 . 2 . 295–302 . 1988 . 2457513 . 10.1016/0014-5793(88)80041-3 . 8083622 . free .
• Lee YL, Hintz RL, James PM, etal . Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors. . Mol. Endocrinol. . 2 . 5 . 404–11 . 1988 . 2458522 . 10.1210/mend-2-5-404 . free .
• Luthman H, Söderling-Barros J, Persson B, etal . Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning. . Eur. J. Biochem. . 180 . 2 . 259–65 . 1989 . 2466665 . 10.1111/j.1432-1033.1989.tb14641.x . free .
• Cubbage ML, Suwanichkul A, Powell DR . Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein. . Mol. Endocrinol. . 3 . 5 . 846–51 . 1989 . 2474129 . 10.1210/mend-3-5-846 . free .
• Alitalo T, Kontula K, Koistinen R, etal . The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism. . Hum. Genet. . 83 . 4 . 335–8 . 1989 . 2478445 . 10.1007/BF00291377 . 20571796 .
• Brinkman A, Groffen CA, Kortleve DJ, Drop SL . Organization of the gene encoding the insulin-like growth factor binding protein IBP-1. . Biochem. Biophys. Res. Commun. . 157 . 3 . 898–907 . 1989 . 2849945 . 10.1016/S0006-291X(88)80959-8 .
• Busby WH, Klapper DG, Clemmons DR . Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. . J. Biol. Chem. . 263 . 28 . 14203–10 . 1988 . 10.1016/S0021-9258(18)68206-7 . 2971653 . free .
• Grundmann U, Nerlich C, Bohn H, Rein T . Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin. . Nucleic Acids Res. . 16 . 17 . 8711 . 1988 . 3419931 . 10.1093/nar/16.17.8711 . 338590 .
• Jones JI, Gockerman A, Busby WH, etal . Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 22 . 10553–7 . 1993 . 7504269 . 10.1073/pnas.90.22.10553 . 47815 . 1993PNAS...9010553J . free .
• Jones JI, Busby WH, Wright G, etal . Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. . J. Biol. Chem. . 268 . 2 . 1125–31 . 1993 . 10.1016/S0021-9258(18)54050-3 . 7678248 . free .

Notes and References

1. Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL . Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1) . EMBO J . 7 . 8 . 2417–23 . Jan 1989 . 2461294 . 457109 . 10.1002/j.1460-2075.1988.tb03087.x.
2. Web site: Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1.