Inositol pentakisphosphate explained

Inositol pentakisphosphate (abbreviated IP5) is a molecule derived from inositol tetrakisphosphate by adding a phosphate group with the help of Inositol-polyphosphate multikinase (IPMK). It is believed to be one of the many second messengers in the inositol phosphate family. It "is implicated in a wide array of biological and pathophysiological responses, including tumorigenesis, invasion and metastasis, therefore specific inhibitors of the kinase may prove useful in cancer therapy."^[1]

IP5 also plays a role in defense signaling in plants. It potentiates the interaction of the plant hormone JA-Ile by its receptor.^{[2] [3]}

Notes and References

1. 14755253 . 2004 . Piccolo . E. . Vignati . S. . Maffucci . T. . Innominato . P. F. . Riley . A. M. . Potter . B. V. . Pandolfi . P. P. . Broggini . M. . Iacobelli . S. . Innocenti . Paolo . Falasca . Marco . Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway . 23 . 9 . 1754–1765 . 10.1038/sj.onc.1207296 . Oncogene. 8 .
2. Sheard . L. B. . 2010 . Jasmonate perception by inositol phosphate-potentiated COI1-JAZ co-receptor. . 468 . 400–405 . 10.1038/nature09430 . 20927106 . 2988090 . 7322 . Tan . Xu . Mao . Haibin . Withers . John . Ben-Nissan . Gili . Hinds . Thomas R. . Kobayashi . Yuichi . Hsu . Fong-Fu . Sharon . Michal. Browse . John . He . Sheng Yang . Rizo . Josep . Howe . Gregg A. . Zheng . Ning . 2010Natur.468..400S . 8 .
3. Mosblech . A. . 2010 . Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana . . 65 . 6 . 949–957 . 10.1111/j.1365-313X.2011.04480.x . 21205029 . Thurow . Corinna . Gatz . Christiane . Feussner . Ivo . Heilmann . Ingo. free .