Inositol-hexakisphosphate kinase explained
| Inositol-hexakisphosphate kinase |
| Ec Number: | 2.7.4.21 |
| Cas Number: | 176898-37-6 |
Inositol-hexakisphosphate kinase (ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1] [2] [3] This enzyme catalyses the following chemical reaction
(1) ATP + 1D-myo-inositol hexakisphosphate(Phytic acid)
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)
Three mammalian isoforms are known to exist.
See also
Notes and References
- Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH . Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases . Current Biology . 9 . 22 . 1323–6 . November 1999 . 10574768 . 10.1016/S0960-9822(00)80055-X . free .
- Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF . PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase . FEBS Letters . 461 . 3 . 169–72 . November 1999 . 10567691 . 10.1016/S0014-5793(99)01462-3 .
- Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW . Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells . The Biochemical Journal . 327 (Pt 2) . 2 . 553–60 . October 1997 . 9359429 . 1218829 . 10.1042/bj3270553 .
