Inositol-1,4-bisphosphate 1-phosphatase explained

inositol-1,4-bisphosphate 1-phosphatase
Ec Number:	3.1.3.57
Cas Number:	111070-17-8
Go Code:	0004441

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

1D-myo-inositol 1,4-bisphosphate + H₂O

\rightleftharpoons 1D-myo-inositol 4-phosphate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF . 1983 . Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides . Biochem. J. . 212 . 473 - 82 . 6309146 . 2 . 10.1042/bj2120473 . 1152070 .
• Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW . 1987 . The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes . J. Biol. Chem. . 262 . 2146 - 9 . 3029066 . 5 .
• Inhorn RC, Majerus PW . 1987 . Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li⁺, Ca²⁺, and Mn²⁺ . J. Biol. Chem. . 262 . 15946 - 52 . 2824473 . 33 .