Ineffective erythropoiesis explained

Ineffective erythropoiesis is defined by the expansion of early-stage erythroid precursors driven by erythropoietin, accompanied by the apoptosis of late-stage precursors. This mechanism is principally responsible for the anemia seen in acquired conditions such as certain subtypes of myelodysplastic syndrome (MDS) and inherited disorders such as β-thalassemia, inherited sideroblastic anemias, as well as congenital dyserythropoietic anemias.^[1]

See also

• Congenital dyserythropoietic anemias
• List of hematologic conditions

Further reading

• Jean-Antoine. Ribeil . Jean-Benoit . Arlet . Michael . Dussiot. Ivan . Cruz Moura . Ineffective Erythropoiesis in β-Thalassemia . The Scientific World Journal. 28 March 2013 . 2356-6140 . e394295 . 2013 . 10.1155/2013/394295 . Geneviève . Courtois . Olivier . Hermine . free . 23606813 . none. 3628659 .
• Toshihiko . Tanno. Jeffery L. . Miller . Iron Loading and Overloading due to Ineffective Erythropoiesis . Advances in Hematology. 11 May 2010 . 1687-9104 . e358283 . 2010 . 10.1155/2010/358283 . free . none.
• Stefano . Rivella . Ineffective erythropoiesis and thalassemias . Current Opinion in Hematology . 2013 . 1065-6251 . 187–194 . 16 . 3 . 19318943 . 3703923 . 10.1097/MOH.0b013e32832990a4 . free . none.
• Ritama . Gupta. Khaled M. . Musallam . Ali T. . Taher . Stefano . Rivella . Ineffective Erythropoiesis, Anemia and Iron Overload . Hematology/Oncology Clinics of North America . 2019 . 0889-8588 . 213–221 . 32 . 2 . 29458727 . 5824437 . 10.1016/j.hoc.2017.11.009 . free . none.

Notes and References

1. Mario . Cazzola . Ineffective erythropoiesis and its treatment . Blood. 21 April 2022 . 1528-0020 . 2460–2470 . 139 . 16 . 34932791 . 10.1182/blood.2021011045 . free.